Does ability to walk reflect general functionality in inflammatory neuropathies?

PeriNomS Study Group

Research output: Contribution to journalArticle

Abstract

The “ability to walk” is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being “able to walk” represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP, and gammopathy-related neuropathy (MGUSP). A total of 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59), and MGUSP (23) were serially examined (1-year). Predefined arbitrary cut-offs (so-called patients' Functional-Acceptable-Clinical-Thresholds [FACTs]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©). We determined the proportion of patients able to walk outside independently that reached the postulated cut-offs. A mean total of 85%, 39%, and 12% of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I-RODS© bypasses these limitations.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume21
Issue number2
DOIs
StatePublished - 2016

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Benchmarking
Walking

Keywords

  • inflammatory neuropathies
  • outcome research

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Does ability to walk reflect general functionality in inflammatory neuropathies? / PeriNomS Study Group.

In: Journal of the Peripheral Nervous System, Vol. 21, No. 2, 2016, p. 74-81.

Research output: Contribution to journalArticle

@article{414de51fbb6b4e75b858ee22758257ae,
title = "Does ability to walk reflect general functionality in inflammatory neuropathies?",
abstract = "The “ability to walk” is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barr{\'e} syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being “able to walk” represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP, and gammopathy-related neuropathy (MGUSP). A total of 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59), and MGUSP (23) were serially examined (1-year). Predefined arbitrary cut-offs (so-called patients' Functional-Acceptable-Clinical-Thresholds [FACTs]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS{\circledC}). We determined the proportion of patients able to walk outside independently that reached the postulated cut-offs. A mean total of 85{\%}, 39{\%}, and 12{\%} of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I-RODS{\circledC} bypasses these limitations.",
keywords = "inflammatory neuropathies, outcome research",
author = "{PeriNomS Study Group} and Draak, {Thomas H.P.} and Gorson, {Kenneth C.} and Vanhoutte, {Els K.} and {van Nes}, {Sonja I.} and {van Doorn}, {Pieter A.} and David Cornblath and {van den Berg}, {Leonard H.} and Faber, {Catharina G.} and Merkies, {Ingemar S.J.} and Barreira, {A. A.} and D. Bennett and F. Bombelli and V. Bril and A. Campanella and Cats, {E. A.} and Cornblath, {D. R.} and R. Costa and {de Visser}, M. and G. Devigili and {van Doorn}, {P. A.} and Faber, {C. G.} and J. Franques and F. Gallia and Gorson, {K. C.} and Hadden, {R. D.} and Hahn, {A. F.} and Hughes, {R. A.C.} and I. Illa and H. Katzberg and G. Lauria and L{\'e}ger, {J. M.} and Lewis, {R. A.} and Lunn, {M. P.T.} and Merkies, {I. S.J.} and E. Nobile-Orazio and Notermans, {N. C.} and L. Padua and J. Pouget and L. Querol and J. Raaphorst and Reilly, {M. M.} and {van den Berg}, {L. H.} and {Van den Bergh}, {P. Y.K.} and {van der Kooi}, {A. J.} and {van der Pol}, {W. L.} and {van Nes}, {S. I.} and {van Schaik}, {I. N.}",
year = "2016",
doi = "10.1111/jns.12167",
language = "English (US)",
volume = "21",
pages = "74--81",
journal = "Journal of the Peripheral Nervous System",
issn = "1085-9489",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Does ability to walk reflect general functionality in inflammatory neuropathies?

AU - PeriNomS Study Group

AU - Draak, Thomas H.P.

AU - Gorson, Kenneth C.

AU - Vanhoutte, Els K.

AU - van Nes, Sonja I.

AU - van Doorn, Pieter A.

AU - Cornblath, David

AU - van den Berg, Leonard H.

AU - Faber, Catharina G.

AU - Merkies, Ingemar S.J.

AU - Barreira, A. A.

AU - Bennett, D.

AU - Bombelli, F.

AU - Bril, V.

AU - Campanella, A.

AU - Cats, E. A.

AU - Cornblath, D. R.

AU - Costa, R.

AU - de Visser, M.

AU - Devigili, G.

AU - van Doorn, P. A.

AU - Faber, C. G.

AU - Franques, J.

AU - Gallia, F.

AU - Gorson, K. C.

AU - Hadden, R. D.

AU - Hahn, A. F.

AU - Hughes, R. A.C.

AU - Illa, I.

AU - Katzberg, H.

AU - Lauria, G.

AU - Léger, J. M.

AU - Lewis, R. A.

AU - Lunn, M. P.T.

AU - Merkies, I. S.J.

AU - Nobile-Orazio, E.

AU - Notermans, N. C.

AU - Padua, L.

AU - Pouget, J.

AU - Querol, L.

AU - Raaphorst, J.

AU - Reilly, M. M.

AU - van den Berg, L. H.

AU - Van den Bergh, P. Y.K.

AU - van der Kooi, A. J.

AU - van der Pol, W. L.

AU - van Nes, S. I.

AU - van Schaik, I. N.

PY - 2016

Y1 - 2016

N2 - The “ability to walk” is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being “able to walk” represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP, and gammopathy-related neuropathy (MGUSP). A total of 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59), and MGUSP (23) were serially examined (1-year). Predefined arbitrary cut-offs (so-called patients' Functional-Acceptable-Clinical-Thresholds [FACTs]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©). We determined the proportion of patients able to walk outside independently that reached the postulated cut-offs. A mean total of 85%, 39%, and 12% of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I-RODS© bypasses these limitations.

AB - The “ability to walk” is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, it has never been determined whether being “able to walk” represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with GBS, CIDP, and gammopathy-related neuropathy (MGUSP). A total of 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59), and MGUSP (23) were serially examined (1-year). Predefined arbitrary cut-offs (so-called patients' Functional-Acceptable-Clinical-Thresholds [FACTs]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory-Rasch-built-Overall-Disability-Scale (I-RODS©). We determined the proportion of patients able to walk outside independently that reached the postulated cut-offs. A mean total of 85%, 39%, and 12% of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I-RODS© bypasses these limitations.

KW - inflammatory neuropathies

KW - outcome research

UR - http://www.scopus.com/inward/record.url?scp=85011337727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011337727&partnerID=8YFLogxK

U2 - 10.1111/jns.12167

DO - 10.1111/jns.12167

M3 - Article

C2 - 26968437

AN - SCOPUS:85011337727

VL - 21

SP - 74

EP - 81

JO - Journal of the Peripheral Nervous System

JF - Journal of the Peripheral Nervous System

SN - 1085-9489

IS - 2

ER -