Do inflammatory biomarkers add to the discrimination of cardiovascular disease after allowing for social deprivation? Results from a 10-year cohort study in Glasgow, Scotland

Mark Woodward, Paul Welsh, Ann Rumley, Hugh Tunstall-Pedoe, Gordon D.O. Lowe

Research output: Contribution to journalArticle

Abstract

Aims To assess the additional discriminative value of adding each of five inflammatory biomarkers to the ASSIGN risk score, which includes social deprivation. Methods and resultsIn this study, 1319 men and women aged 25-64 in the fourth Glasgow MONICA study were followed-up for cardiovascular endpoints. Baseline C-reactive protein, fibrinogen, IL-6, IL-18, and TNFα were related to risk of CVD. The discriminative value of adding each to the ASSIGN score was assessed using area under the receiver operating characteristic (AUC) and relative integrated percentage improvement in classification (RIDI). During a median of 10.5 years, 151 CVD events occurred. After adjusting for ASSIGN variables, each inflammatory marker except IL-18 had a significant (P < 0.05) association with CVD risk. The AUC using ASSIGN [0.799 (95 CI 0.790-0.809)] was improved by the inclusion of C-reactive protein and TNFα [0.805 (95 CI 0.795-0.815); P < 0.03], but not by other combinations. C-reactive protein and TNFα yielded a significant RIDI (IL-6 almost so). C-reactive protein and TNFα together improved the classification of risk by 11 (95 CI, 3-19) when added to the ASSIGN variables. Conclusion Some inflammatory biomarkers add moderate discriminative information to the ASSIGN CVD risk score. The clinical utility of this information, cost-effectiveness, and optimization should be assessed in future studies.

Original languageEnglish (US)
Pages (from-to)2669-2675
Number of pages7
JournalEuropean heart journal
Volume31
Issue number21
DOIs
StatePublished - Nov 1 2010

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Keywords

  • C-reactive protein
  • Cardiovascular disease
  • Fibrinogen
  • Inflammation
  • Risk prediction
  • Social deprivation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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