Do humans show velocity-storage in the vertical rVOR?

G. Bertolini, C. J. Bockisch, D. Straumann, David Samuel Zee, S. Ramat

Research output: Contribution to journalArticle

Abstract

To investigate the contribution of the vestibular velocity-storage mechanism (VSM) to the vertical rotational vestibulo-ocular reflex (rVOR) we recorded eye movements evoked by off-vertical axis rotation (OVAR) using whole-body constant-velocity pitch rotations about an earth-horizontal, interaural axis in four healthy human subjects. Subjects were tumbled forward, and backward, at 60 deg/s for over 1 min using a 3D turntable. Slow-phase velocity (SPV) responses were similar to the horizontal responses elicited by OVAR along the body longitudinal axis, ('barbecue' rotation), with exponentially decaying amplitudes and a residual, otolith-driven sinusoidal response with a bias. The time constants of the vertical SPV ranged from 6 to 9 s. These values are closer to those that reflect the dynamic properties of vestibular afferents than the typical 20 s produced by the VSM in the horizontal plane, confirming the relatively smaller contribution of the VSM to these vertical responses. Our preliminary results also agree with the idea that the VSM velocity response aligns with the direction of gravity. The horizontal and torsional eye velocity traces were also sinusoidally modulated by the change in gravity, but showed no exponential decay.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalProgress in Brain Research
Volume171
DOIs
StatePublished - 2008

Fingerprint

Vestibulo-Ocular Reflex
Gravitation
Otolithic Membrane
Eye Movements
Healthy Volunteers

Keywords

  • pitch VOR
  • rVOR
  • velocity-storage mechanism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Do humans show velocity-storage in the vertical rVOR? / Bertolini, G.; Bockisch, C. J.; Straumann, D.; Zee, David Samuel; Ramat, S.

In: Progress in Brain Research, Vol. 171, 2008, p. 207-210.

Research output: Contribution to journalArticle

Bertolini, G. ; Bockisch, C. J. ; Straumann, D. ; Zee, David Samuel ; Ramat, S. / Do humans show velocity-storage in the vertical rVOR?. In: Progress in Brain Research. 2008 ; Vol. 171. pp. 207-210.
@article{ce06543ea12940778df77027447aa1a2,
title = "Do humans show velocity-storage in the vertical rVOR?",
abstract = "To investigate the contribution of the vestibular velocity-storage mechanism (VSM) to the vertical rotational vestibulo-ocular reflex (rVOR) we recorded eye movements evoked by off-vertical axis rotation (OVAR) using whole-body constant-velocity pitch rotations about an earth-horizontal, interaural axis in four healthy human subjects. Subjects were tumbled forward, and backward, at 60 deg/s for over 1 min using a 3D turntable. Slow-phase velocity (SPV) responses were similar to the horizontal responses elicited by OVAR along the body longitudinal axis, ('barbecue' rotation), with exponentially decaying amplitudes and a residual, otolith-driven sinusoidal response with a bias. The time constants of the vertical SPV ranged from 6 to 9 s. These values are closer to those that reflect the dynamic properties of vestibular afferents than the typical 20 s produced by the VSM in the horizontal plane, confirming the relatively smaller contribution of the VSM to these vertical responses. Our preliminary results also agree with the idea that the VSM velocity response aligns with the direction of gravity. The horizontal and torsional eye velocity traces were also sinusoidally modulated by the change in gravity, but showed no exponential decay.",
keywords = "pitch VOR, rVOR, velocity-storage mechanism",
author = "G. Bertolini and Bockisch, {C. J.} and D. Straumann and Zee, {David Samuel} and S. Ramat",
year = "2008",
doi = "10.1016/S0079-6123(08)00628-6",
language = "English (US)",
volume = "171",
pages = "207--210",
journal = "Progress in Brain Research",
issn = "0079-6123",
publisher = "Elsevier",

}

TY - JOUR

T1 - Do humans show velocity-storage in the vertical rVOR?

AU - Bertolini, G.

AU - Bockisch, C. J.

AU - Straumann, D.

AU - Zee, David Samuel

AU - Ramat, S.

PY - 2008

Y1 - 2008

N2 - To investigate the contribution of the vestibular velocity-storage mechanism (VSM) to the vertical rotational vestibulo-ocular reflex (rVOR) we recorded eye movements evoked by off-vertical axis rotation (OVAR) using whole-body constant-velocity pitch rotations about an earth-horizontal, interaural axis in four healthy human subjects. Subjects were tumbled forward, and backward, at 60 deg/s for over 1 min using a 3D turntable. Slow-phase velocity (SPV) responses were similar to the horizontal responses elicited by OVAR along the body longitudinal axis, ('barbecue' rotation), with exponentially decaying amplitudes and a residual, otolith-driven sinusoidal response with a bias. The time constants of the vertical SPV ranged from 6 to 9 s. These values are closer to those that reflect the dynamic properties of vestibular afferents than the typical 20 s produced by the VSM in the horizontal plane, confirming the relatively smaller contribution of the VSM to these vertical responses. Our preliminary results also agree with the idea that the VSM velocity response aligns with the direction of gravity. The horizontal and torsional eye velocity traces were also sinusoidally modulated by the change in gravity, but showed no exponential decay.

AB - To investigate the contribution of the vestibular velocity-storage mechanism (VSM) to the vertical rotational vestibulo-ocular reflex (rVOR) we recorded eye movements evoked by off-vertical axis rotation (OVAR) using whole-body constant-velocity pitch rotations about an earth-horizontal, interaural axis in four healthy human subjects. Subjects were tumbled forward, and backward, at 60 deg/s for over 1 min using a 3D turntable. Slow-phase velocity (SPV) responses were similar to the horizontal responses elicited by OVAR along the body longitudinal axis, ('barbecue' rotation), with exponentially decaying amplitudes and a residual, otolith-driven sinusoidal response with a bias. The time constants of the vertical SPV ranged from 6 to 9 s. These values are closer to those that reflect the dynamic properties of vestibular afferents than the typical 20 s produced by the VSM in the horizontal plane, confirming the relatively smaller contribution of the VSM to these vertical responses. Our preliminary results also agree with the idea that the VSM velocity response aligns with the direction of gravity. The horizontal and torsional eye velocity traces were also sinusoidally modulated by the change in gravity, but showed no exponential decay.

KW - pitch VOR

KW - rVOR

KW - velocity-storage mechanism

UR - http://www.scopus.com/inward/record.url?scp=49349104891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49349104891&partnerID=8YFLogxK

U2 - 10.1016/S0079-6123(08)00628-6

DO - 10.1016/S0079-6123(08)00628-6

M3 - Article

C2 - 18718302

AN - SCOPUS:49349104891

VL - 171

SP - 207

EP - 210

JO - Progress in Brain Research

JF - Progress in Brain Research

SN - 0079-6123

ER -