Do GOLD stages of COPD severity really correspond to differences in health status?

R. Antonelli-Incalzi; C. Imperiale; V. Bellia; F. Catalano; N. Scichilone; R. Pistelli; F. Rengo; V. Grassi; G. Masotti; S. Maggi; D. Olivieri; G. Melillo; M. Palleschi; M. Trabucchi; S. Zuccaro; D. L. Consales; P. Paggi; D. Lo Nardo; F. Goria; P. Fea; G. Iraldi; R. Corradi; A. Capurso; R. Flora; F. Torres; G. Venezia; M. Mesto; R. Valerio; R. Noya; G. Argentieri; S. Semeraro; L. Bellotti; A. Tansella; V. Grassi; S. Cossi; G. Guerini; C. Fantoni; M. De Martinis; L. Pini; V. Pinelli; G. Melillo; R. Battiloro; C. Gaudiosi; S. De Angelis; L. Motta; D. Mugeri; I. Alessandria; S. Savia; G. Masotti; M. Chiarlone; D. Matteuzzi; S. Zacchei; V. Pedone; D. Angelini; D. Cilla; E. Palummeri; D. Torriglia; M. Agretti; P. Costelli; A. Giusti; M. Trabucchi; P. Ranieri; F. Guerini; P. Barbisoni; P. Calabrese; F. Caione; D. Caione; M. La Chiara; G. Galetti; A. Cantatore; D. Casarotti; G. Anni; B. Grumelli; F. Rengo; F. Cacciatore; A. I. Pisacreta; C. Calabrese; V. Carnevale; P. Abete; G. Enzi; S. Peruzza; P. Dalla Montà; P. Albanese; F. Tiozzo; D. Olivieri; V. Bocchino; A. Comel; N. Barbarito; M. Barbera; U. Senin; S. Peretti; F. Arnone; L. Camilli; S. M. Zuccaro; M. Marchetti; L. Palleschi; M. Palleschi; C. Cieri; F. Vetta

doi:10.1183/09031936.03.00101203

Do GOLD stages of COPD severity really correspond to differences in health status?

R. Antonelli-Incalzi, C. Imperiale, V. Bellia, F. Catalano, N. Scichilone, R. Pistelli, F. Rengo, V. Grassi, G. Masotti, S. Maggi, D. Olivieri, G. Melillo, M. Palleschi, M. Trabucchi, S. Zuccaro, D. L. Consales, P. Paggi, D. Lo Nardo, F. Goria, P. FeaG. Iraldi, R. Corradi, A. Capurso, R. Flora, F. Torres, G. Venezia, M. Mesto, R. Valerio, R. Noya, G. Argentieri, S. Semeraro, L. Bellotti, A. Tansella, V. Grassi, S. Cossi, G. Guerini, C. Fantoni, M. De Martinis, L. Pini, V. Pinelli, G. Melillo, R. Battiloro, C. Gaudiosi, S. De Angelis, L. Motta, D. Mugeri, I. Alessandria, S. Savia, G. Masotti, M. Chiarlone, D. Matteuzzi, S. Zacchei, V. Pedone, D. Angelini, D. Cilla, E. Palummeri, D. Torriglia, M. Agretti, P. Costelli, A. Giusti, M. Trabucchi, P. Ranieri, F. Guerini, P. Barbisoni, P. Calabrese, F. Caione, D. Caione, M. La Chiara, G. Galetti, A. Cantatore, D. Casarotti, G. Anni, B. Grumelli, F. Rengo, F. Cacciatore, A. I. Pisacreta, C. Calabrese, V. Carnevale, P. Abete, G. Enzi, S. Peruzza, P. Dalla Montà, P. Albanese, F. Tiozzo, D. Olivieri, V. Bocchino, A. Comel, N. Barbarito, M. Barbera, U. Senin, S. Peretti, F. Arnone, L. Camilli, S. M. Zuccaro, M. Marchetti, L. Palleschi, M. Palleschi, C. Cieri, F. Vetta

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

The purpose of this study was to assess whether different stages of chronic obstructive pulmonary disease (COPD) severity defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria correlate with meaningful differences in health status. A total of 381 COPD patients, aged 73±6 yrs, were classified in the five GOLD stages. Disease-specific (St George Respiratory Questionnaire (SGRQ)) and generic indexes of health status were measured in all patients. Multivariate analysis of covariance or Kruskal Wallis tests were used to compare health status indexes across the spectrum of GOLD stages of COPD severity. GOLD stages of COPD severity significantly differed in SGRQ components and Barthel's index, but not in the indexes assessing cognitive and affective status and quality of sleep. The largest variation in health status was observed at the transition from stage IIa to stage IIb, while there were no other significant differences between consecutive stages. Both female sex and comorbidity were associated with a greater impact of COPD on the health status. In conclusion, the upper limit of stage IIb (forced expiratory volume in one second of 49%) marks a threshold for dramatic worsening of health status. Progression of chronic obstructive pulmonary disease severity from stage 0 to stage IIa does not correspond to any meaningful difference in health status.

Original language	English (US)
Pages (from-to)	444-449
Number of pages	6
Journal	European Respiratory Journal
Volume	22
Issue number	3
DOIs	https://doi.org/10.1183/09031936.03.00101203
State	Published - Sep 1 2003
Externally published	Yes

Keywords

Chronic obstructive pulmonary disease
Elderly
Global initiative for chronic obstructive lung disease guidelines
Health status

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1183/09031936.03.00101203

Cite this

Antonelli-Incalzi, R., Imperiale, C., Bellia, V., Catalano, F., Scichilone, N., Pistelli, R., Rengo, F., Grassi, V., Masotti, G., Maggi, S., Olivieri, D., Melillo, G., Palleschi, M., Trabucchi, M., Zuccaro, S., Consales, D. L., Paggi, P., Lo Nardo, D., Goria, F., ... Vetta, F. (2003). Do GOLD stages of COPD severity really correspond to differences in health status? European Respiratory Journal, 22(3), 444-449. https://doi.org/10.1183/09031936.03.00101203

Antonelli-Incalzi, R, Imperiale, C, Bellia, V, Catalano, F, Scichilone, N, Pistelli, R, Rengo, F, Grassi, V, Masotti, G, Maggi, S, Olivieri, D, Melillo, G, Palleschi, M, Trabucchi, M, Zuccaro, S, Consales, DL, Paggi, P, Lo Nardo, D, Goria, F, Fea, P, Iraldi, G, Corradi, R, Capurso, A, Flora, R, Torres, F, Venezia, G, Mesto, M, Valerio, R, Noya, R, Argentieri, G, Semeraro, S, Bellotti, L, Tansella, A, Grassi, V, Cossi, S, Guerini, G, Fantoni, C, De Martinis, M, Pini, L, Pinelli, V, Melillo, G, Battiloro, R, Gaudiosi, C, De Angelis, S, Motta, L, Mugeri, D, Alessandria, I, Savia, S, Masotti, G, Chiarlone, M, Matteuzzi, D, Zacchei, S, Pedone, V, Angelini, D, Cilla, D, Palummeri, E, Torriglia, D, Agretti, M, Costelli, P, Giusti, A, Trabucchi, M, Ranieri, P, Guerini, F, Barbisoni, P, Calabrese, P, Caione, F, Caione, D, La Chiara, M, Galetti, G, Cantatore, A, Casarotti, D, Anni, G, Grumelli, B, Rengo, F, Cacciatore, F, Pisacreta, AI, Calabrese, C, Carnevale, V, Abete, P, Enzi, G, Peruzza, S, Dalla Montà, P, Albanese, P, Tiozzo, F, Olivieri, D, Bocchino, V, Comel, A, Barbarito, N, Barbera, M, Senin, U, Peretti, S, Arnone, F, Camilli, L, Zuccaro, SM, Marchetti, M, Palleschi, L, Palleschi, M, Cieri, C & Vetta, F 2003, 'Do GOLD stages of COPD severity really correspond to differences in health status?', European Respiratory Journal, vol. 22, no. 3, pp. 444-449. https://doi.org/10.1183/09031936.03.00101203

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title = "Do GOLD stages of COPD severity really correspond to differences in health status?",

abstract = "The purpose of this study was to assess whether different stages of chronic obstructive pulmonary disease (COPD) severity defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria correlate with meaningful differences in health status. A total of 381 COPD patients, aged 73±6 yrs, were classified in the five GOLD stages. Disease-specific (St George Respiratory Questionnaire (SGRQ)) and generic indexes of health status were measured in all patients. Multivariate analysis of covariance or Kruskal Wallis tests were used to compare health status indexes across the spectrum of GOLD stages of COPD severity. GOLD stages of COPD severity significantly differed in SGRQ components and Barthel's index, but not in the indexes assessing cognitive and affective status and quality of sleep. The largest variation in health status was observed at the transition from stage IIa to stage IIb, while there were no other significant differences between consecutive stages. Both female sex and comorbidity were associated with a greater impact of COPD on the health status. In conclusion, the upper limit of stage IIb (forced expiratory volume in one second of 49%) marks a threshold for dramatic worsening of health status. Progression of chronic obstructive pulmonary disease severity from stage 0 to stage IIa does not correspond to any meaningful difference in health status.",

keywords = "Chronic obstructive pulmonary disease, Elderly, Global initiative for chronic obstructive lung disease guidelines, Health status",

author = "R. Antonelli-Incalzi and C. Imperiale and V. Bellia and F. Catalano and N. Scichilone and R. Pistelli and F. Rengo and V. Grassi and G. Masotti and S. Maggi and D. Olivieri and G. Melillo and M. Palleschi and M. Trabucchi and S. Zuccaro and Consales, {D. L.} and P. Paggi and {Lo Nardo}, D. and F. Goria and P. Fea and G. Iraldi and R. Corradi and A. Capurso and R. Flora and F. Torres and G. Venezia and M. Mesto and R. Valerio and R. Noya and G. Argentieri and S. Semeraro and L. Bellotti and A. Tansella and V. Grassi and S. Cossi and G. Guerini and C. Fantoni and {De Martinis}, M. and L. Pini and V. Pinelli and G. Melillo and R. Battiloro and C. Gaudiosi and {De Angelis}, S. and L. Motta and D. Mugeri and I. Alessandria and S. Savia and G. Masotti and M. Chiarlone and D. Matteuzzi and S. Zacchei and V. Pedone and D. Angelini and D. Cilla and E. Palummeri and D. Torriglia and M. Agretti and P. Costelli and A. Giusti and M. Trabucchi and P. Ranieri and F. Guerini and P. Barbisoni and P. Calabrese and F. Caione and D. Caione and {La Chiara}, M. and G. Galetti and A. Cantatore and D. Casarotti and G. Anni and B. Grumelli and F. Rengo and F. Cacciatore and Pisacreta, {A. I.} and C. Calabrese and V. Carnevale and P. Abete and G. Enzi and S. Peruzza and {Dalla Mont{\`a}}, P. and P. Albanese and F. Tiozzo and D. Olivieri and V. Bocchino and A. Comel and N. Barbarito and M. Barbera and U. Senin and S. Peretti and F. Arnone and L. Camilli and Zuccaro, {S. M.} and M. Marchetti and L. Palleschi and M. Palleschi and C. Cieri and F. Vetta",

year = "2003",

month = sep,

day = "1",

doi = "10.1183/09031936.03.00101203",

language = "English (US)",

volume = "22",

pages = "444--449",

journal = "European Respiratory Journal",

issn = "0903-1936",