Do genes modify the association of selenium and lipid levels?

Inmaculada Galan-Chilet, Eliseo Guallar, J. Carlos Martin-Escudero, Griselda De Marco, Alejandro Dominguez-Lucas, Isabel Gonzalez-Manzano, Raul Lopez-Izquierdo, Josep Redon, F. Javier Chaves, Maria Tellez-Plaza

Research output: Contribution to journalReview article

Abstract

The interaction of selenium, a component of antioxidant selenoproteins, with genetic variation in lipid-related pathways has not been evaluated earlier as a potential determinant of blood lipid levels. We aimed at evaluating the effects of gene-environment interactions between plasma levels of selenium and polymorphisms in lipid metabolic pathways on plasma lipid levels in a study population from Spain (N=1,315). We observed statistically significant associations between plasma selenium and lipid levels (differences in total, low-density lipoprotein [LDL]-cholesterol, and triglycerides comparing the 80th with the 20th percentiles of plasma selenium levels were, respectively, 12.0 (95% confidence interval 6.3, 17.8), 8.9 (3.7, 14.2), and 9.0 (2.9, 15.2) mg/dl). We also found statistically significant interactions at the Bonferroni-corrected significance level (p=0.0008) between selenium and rs2290201 in FABP4 for total and LDL cholesterol levels and rs1800774 in CETP for elevated LDL cholesterol. Other polymorphisms showed statistically significant differential associations of plasma selenium levels and lipids biomarkers at the nominal p-value of 0.05. Reported statistical interactions with genes involved in lipid transport and transfer provide biological support to the positive associations of selenium with lipids shown in cross-sectional studies and lead to the hypothesis that selenium and lipid levels share common biological pathways that need to be elucidated in mechanistic studies. Antioxid. Redox Signal. 22, 1352-1362.

Original languageEnglish (US)
Pages (from-to)1352-1362
Number of pages11
JournalAntioxidants and Redox Signaling
Volume22
Issue number15
DOIs
StatePublished - May 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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  • Cite this

    Galan-Chilet, I., Guallar, E., Martin-Escudero, J. C., De Marco, G., Dominguez-Lucas, A., Gonzalez-Manzano, I., Lopez-Izquierdo, R., Redon, J., Chaves, F. J., & Tellez-Plaza, M. (2015). Do genes modify the association of selenium and lipid levels? Antioxidants and Redox Signaling, 22(15), 1352-1362. https://doi.org/10.1089/ars.2015.6248