Do environmental factors modify the genetic risk of prostate cancer?

Stacy Loeb, Sarah B. Peskoe, Corinne E. Joshu, Wen Yi Huang, Richard B. Hayes, H Ballentine Carter, William B Isaacs, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

Background: Many SNPs influence prostate cancer risk. To what extent genetic risk can be reduced by environmental factors is unknown. Methods: We evaluated effect modification by environmental factors of the association between susceptibility SNPs and prostate cancer in 1,230 incident prostate cancer cases and 1,361 controls, all white and similar ages, nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Trial. Genetic risk scores were calculated as number of risk alleles for 20 validated SNPs.We estimated the association between higher genetic risk (≥12 SNPs) and prostate cancer within environmental factor strata and tested for interaction. Results: Men with ≥12 risk alleles had 1.98, 2.04, and 1.91 times the odds of total, advanced, and nonadvanced prostate cancer, respectively. These associations were attenuated with the use of selenium supplements, aspirin, ibuprofen, and higher vegetable intake. For selenium, the attenuation was most striking for advanced prostate cancer: compared with interaction = 0.031). Aspirin had the most marked attenuation for nonadvanced prostate cancer: compared with interaction = 0.009). This pattern was similar for ibuprofen (Pinteraction = 0.023) and vegetables (Pinteraction = 0.010). Conclusions: This study suggests that selenium supplements may reduce genetic risk of advanced prostate cancer, whereas aspirin, ibuprofen, and vegetables may reduce genetic risk of nonadvanced prostate cancer. Impact: The effect of genetic factors on prostate cancer risk may vary by lifestyle interventions.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2015

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Prostatic Neoplasms
Single Nucleotide Polymorphism
Ibuprofen
Selenium
Vegetables
Aspirin
Alleles
Ovarian Neoplasms
Life Style
Colorectal Neoplasms
Lung Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Do environmental factors modify the genetic risk of prostate cancer? / Loeb, Stacy; Peskoe, Sarah B.; Joshu, Corinne E.; Huang, Wen Yi; Hayes, Richard B.; Carter, H Ballentine; Isaacs, William B; Platz, Elizabeth A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 1, 01.01.2015, p. 213-220.

Research output: Contribution to journalArticle

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