Do brainstem omnipause neurons terminate saccades?

Janet C. Rucker, Sarah H. Ying, Willa Moore, Lance M. Optican, Jean Büttner-Ennever, Edward L. Keller, Barbara E. Shapiro, R. John Leigh

Research output: Contribution to journalArticle

Abstract

Saccade-generating burst neurons (BN) are inhibited by omnipause neurons (OPN), except during saccades. OPN activity pauses before saccade onset and resumes at the saccade end. Microstimulation of OPN stops saccades in mid-flight, which shows that OPN can end saccades. However, OPN pause duration does not correlate well with saccade duration, and saccades are normometric after OPN lesions. We tested whether OPN were responsible for stopping saccades both in late-onset Tay-Sachs, which causes premature saccadic termination, and in individuals with cerebellar hypermetria. We studied gaze shifts between two targets at different distances aligned on one eye, which consist of a disjunctive saccade followed by vergence. High-frequency conjugate oscillations during the vergence movements that followed saccades were present in all subjects studied, indicating OPN silence. Thus, mechanisms other than OPN discharge (e.g., cerebellar caudal fastigial nucleus-promoting inhibitory BN discharge) must contribute to saccade termination.

Original languageEnglish (US)
Pages (from-to)48-57
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1233
Issue number1
DOIs
StatePublished - Sep 2011

Fingerprint

Eye movements
Saccades
Brain Stem
Neurons
Neuron
Cerebellar Nuclei
Cerebellar Ataxia

Keywords

  • Fastigial nucleus
  • Müller paradigm
  • Omnipause neurons
  • Saccades
  • Tay-Sachs disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Rucker, J. C., Ying, S. H., Moore, W., Optican, L. M., Büttner-Ennever, J., Keller, E. L., ... Leigh, R. J. (2011). Do brainstem omnipause neurons terminate saccades? Annals of the New York Academy of Sciences, 1233(1), 48-57. https://doi.org/10.1111/j.1749-6632.2011.06170.x

Do brainstem omnipause neurons terminate saccades? / Rucker, Janet C.; Ying, Sarah H.; Moore, Willa; Optican, Lance M.; Büttner-Ennever, Jean; Keller, Edward L.; Shapiro, Barbara E.; Leigh, R. John.

In: Annals of the New York Academy of Sciences, Vol. 1233, No. 1, 09.2011, p. 48-57.

Research output: Contribution to journalArticle

Rucker, JC, Ying, SH, Moore, W, Optican, LM, Büttner-Ennever, J, Keller, EL, Shapiro, BE & Leigh, RJ 2011, 'Do brainstem omnipause neurons terminate saccades?', Annals of the New York Academy of Sciences, vol. 1233, no. 1, pp. 48-57. https://doi.org/10.1111/j.1749-6632.2011.06170.x
Rucker JC, Ying SH, Moore W, Optican LM, Büttner-Ennever J, Keller EL et al. Do brainstem omnipause neurons terminate saccades? Annals of the New York Academy of Sciences. 2011 Sep;1233(1):48-57. https://doi.org/10.1111/j.1749-6632.2011.06170.x
Rucker, Janet C. ; Ying, Sarah H. ; Moore, Willa ; Optican, Lance M. ; Büttner-Ennever, Jean ; Keller, Edward L. ; Shapiro, Barbara E. ; Leigh, R. John. / Do brainstem omnipause neurons terminate saccades?. In: Annals of the New York Academy of Sciences. 2011 ; Vol. 1233, No. 1. pp. 48-57.
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