Do biofilms confer a pro-carcinogenic state?

Christine M. Dejea, Cynthia L. Sears

Research output: Contribution to journalArticlepeer-review

Abstract

It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cancer. Our recent work reveals that the organization of the mucosal microbiota into biofilms marks a subset of human colon cancer. Further, biofilm-positive colon mucosa in the colon cancer host yields an infrequently detected polyamine metabolite, N(1), N(12)-diacetylspermine, that deserves further study to determine its utility as a marker for colon neoplasia.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalGut Microbes
Volume7
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • bacteroides
  • biofilm
  • colorectal cancer
  • escherichia coli
  • fusobacterium
  • microbiome
  • screening colonoscopy

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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