DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Kenneth E. Ugen; Susan B. Nyland; Jean D. Boyer; Cristina Vidal; Liana Lera; Sowsan Rasheid; Michael Chattergoon; Mark L. Bagarazzi; Richard Ciccarelli; Terry Higgins; Yaila Baine; Richard Ginsberg; Rob Roy Macgregor; David B. Weiner

doi:10.1016/S0264-410X(98)00180-7

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Kenneth E. Ugen, Susan B. Nyland, Jean D. Boyer, Cristina Vidal, Liana Lera, Sowsan Rasheid, Michael Chattergoon, Mark L. Bagarazzi, Richard Ciccarelli, Terry Higgins, Yaila Baine, Richard Ginsberg, Rob Roy Macgregor, David B. Weiner

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.

Original language	English (US)
Pages (from-to)	1818-1821
Number of pages	4
Journal	Vaccine
Volume	16
Issue number	19
DOIs	https://doi.org/10.1016/S0264-410X(98)00180-7
State	Published - Nov 1998
Externally published	Yes

Keywords

Antibody
DNA plasmid vaccination
ELISA

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(98)00180-7

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title = "DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans",

abstract = "Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.",

keywords = "Antibody, DNA plasmid vaccination, ELISA",

author = "Ugen, {Kenneth E.} and Nyland, {Susan B.} and Boyer, {Jean D.} and Cristina Vidal and Liana Lera and Sowsan Rasheid and Michael Chattergoon and Bagarazzi, {Mark L.} and Richard Ciccarelli and Terry Higgins and Yaila Baine and Richard Ginsberg and Macgregor, {Rob Roy} and Weiner, {David B.}",

year = "1998",

month = nov,

doi = "10.1016/S0264-410X(98)00180-7",

language = "English (US)",

volume = "16",

pages = "1818--1821",

journal = "Vaccine",

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T1 - DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

AU - Ugen, Kenneth E.

AU - Nyland, Susan B.

AU - Boyer, Jean D.

AU - Vidal, Cristina

AU - Lera, Liana

AU - Rasheid, Sowsan

AU - Chattergoon, Michael

AU - Bagarazzi, Mark L.

AU - Ciccarelli, Richard

AU - Higgins, Terry

AU - Baine, Yaila

AU - Ginsberg, Richard

AU - Macgregor, Rob Roy

AU - Weiner, David B.

PY - 1998/11

Y1 - 1998/11

N2 - Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.

AB - Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.

KW - Antibody

KW - DNA plasmid vaccination

KW - ELISA

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DO - 10.1016/S0264-410X(98)00180-7

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AN - SCOPUS:0032210747

VL - 16

SP - 1818

EP - 1821

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 19

ER -

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Abstract

Keywords

ASJC Scopus subject areas

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