DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Kenneth E. Ugen, Susan B. Nyland, Jean D. Boyer, Cristina Vidal, Liana Lera, Sowsan Rasheid, Michael Chattergoon, Mark L. Bagarazzi, Richard Ciccarelli, Terry Higgins, Yaila Baine, Richard Ginsberg, Rob Roy Macgregor, David B. Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Humoral and cellular immune responses have been produced by intramuscular vaccination with DNA plasmids expressing HIV-1 genes, suggesting possible immunotherapeutic and prophylactic value for these constructs. Vaccination with these constructs has decreased HIV-1 viral load in HIV-1-infected chimpanzees. In addition, naive (i.e. non-HIV-1-infected) chimpanzees were protected against a heterologous challenge with HIV-1. Ongoing phase I clinical trials show that therapeutic vaccinations indeed boost anti-HIV-1 immune responses in humans. A therapeutic phase I trial on humans with these constructs induced a good safety profile and also demonstrated an immunological potentiation. These findings indicate that further studies with these constructs in humans are warranted.

Original languageEnglish (US)
Pages (from-to)1818-1821
Number of pages4
JournalVaccine
Volume16
Issue number19
DOIs
StatePublished - Nov 1 1998
Externally publishedYes

Keywords

  • Antibody
  • DNA plasmid vaccination
  • ELISA

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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