Abstract
Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anti-cancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.
Original language | English (US) |
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Pages (from-to) | 597-608 |
Number of pages | 12 |
Journal | Mini reviews in medicinal chemistry |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Sep 2003 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Cancer Research