DNA topoisomerases as targets for antiprotozoal therapy.

Research output: Contribution to journalReview articlepeer-review

Abstract

Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anti-cancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.

Original languageEnglish (US)
Pages (from-to)597-608
Number of pages12
JournalMini reviews in medicinal chemistry
Volume3
Issue number6
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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