DNA topoisomerases: A new twist for antiparasitic chemotherapy?

Elizabeth C. Nenortas, Annette L. Bodley, Theresa A. Shapiro

Research output: Contribution to journalReview articlepeer-review

Abstract

The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1400
Issue number1-3
DOIs
StatePublished - Oct 1 1998

Keywords

  • Inhibitor
  • Malaria
  • Parasite
  • Protozoon
  • Topoisomerase
  • Trypanosome

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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