DNA topoisomerases: A new twist for antiparasitic chemotherapy?

Elizabeth C. Nenortas; Annette L. Bodley; Theresa A. Shapiro

doi:10.1016/S0167-4781(98)00146-8

DNA topoisomerases: A new twist for antiparasitic chemotherapy?

Elizabeth C. Nenortas, Annette L. Bodley, Theresa A. Shapiro

School of Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.

Original language	English (US)
Pages (from-to)	349-354
Number of pages	6
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1400
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-4781(98)00146-8
State	Published - Oct 1 1998

Keywords

Inhibitor
Malaria
Parasite
Protozoon
Topoisomerase
Trypanosome

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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title = "DNA topoisomerases: A new twist for antiparasitic chemotherapy?",

abstract = "The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.",

keywords = "Inhibitor, Malaria, Parasite, Protozoon, Topoisomerase, Trypanosome",

author = "Nenortas, {Elizabeth C.} and {L. Bodley}, Annette and Shapiro, {Theresa A.}",

note = "Funding Information: Work in the author{\textquoteright}s laboratory was supported by the National Institutes of Health (AI28855) and by a Scholar Award in Experimental Therapeutics from the Burroughs Wellcome Fund.",

year = "1998",

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T1 - DNA topoisomerases

T2 - A new twist for antiparasitic chemotherapy?

AU - Nenortas, Elizabeth C.

AU - L. Bodley, Annette

AU - Shapiro, Theresa A.

N1 - Funding Information: Work in the author’s laboratory was supported by the National Institutes of Health (AI28855) and by a Scholar Award in Experimental Therapeutics from the Burroughs Wellcome Fund.

PY - 1998/10/1

Y1 - 1998/10/1

N2 - The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.

AB - The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.

KW - Inhibitor

KW - Malaria

KW - Parasite

KW - Protozoon

KW - Topoisomerase

KW - Trypanosome

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DO - 10.1016/S0167-4781(98)00146-8

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AN - SCOPUS:0032189254

SN - 0167-4781

VL - 1400

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 1-3

ER -

DNA topoisomerases: A new twist for antiparasitic chemotherapy?

Abstract

Keywords

ASJC Scopus subject areas

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