DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells

R. A. Vincent, R. B. Sheridan, P. C. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of X-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and X-ray induced chromatid abberations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume33
Issue number2-3
DOIs
StatePublished - Dec 1975

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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