DNA repair, genome stability, and aging

David B. Lombard, Katrin F. Chua, Raul Mostoslavsky, Sonia Franco, Monica Gostissa, Frederick W. Alt

Research output: Contribution to journalReview articlepeer-review


Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability, metabolism, and aging. We conclude with a general discussion of the role of mutant mice in aging research and avenues for future investigation.

Original languageEnglish (US)
Pages (from-to)497-512
Number of pages16
Issue number4
StatePublished - Feb 25 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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