Abstract
DNA methylation is a crucial epigenetic mark in mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for mammalian neuronal functions, and learning and memory. In this review, we first summarize recent discoveries and fundamental principles of DNA modifications in the general epigenetics field. We then describe the profiles of different DNA modifications in the mammalian brain genome. Finally, we discuss roles of DNA modifications in mammalian brain development and function.
| Original language | English (US) |
|---|---|
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 369 |
| Issue number | 1652 |
| DOIs | |
| State | Published - Sep 26 2014 |
Keywords
- 5-hydroxymethylcytosine
- 5-methylcytosine
- DNA methylation
- learning and memory
ASJC Scopus subject areas
- General Medicine