DNA modifications in the mammalian brain

Jaehoon Shin, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

DNA methylation is a crucial epigenetic mark in mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for mammalian neuronal functions, and learning and memory. In this review, we first summarize recent discoveries and fundamental principles of DNA modifications in the general epigenetics field. We then describe the profiles of different DNA modifications in the mammalian brain genome. Finally, we discuss roles of DNA modifications in mammalian brain development and function.

Original languageEnglish (US)
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume369
Issue number1652
DOIs
StatePublished - Sep 26 2014

Keywords

  • 5-hydroxymethylcytosine
  • 5-methylcytosine
  • DNA methylation
  • learning and memory

ASJC Scopus subject areas

  • Medicine(all)

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