Abstract
Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation. DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.
Original language | English (US) |
---|---|
Pages (from-to) | 36-44 |
Number of pages | 9 |
Journal | Prostate |
Volume | 28 |
Issue number | 3 SUPPL. 6 |
DOIs | |
State | Published - Jan 1 1996 |
Keywords
- DNA methylation
- linkage analysis
- prostate cancer
- tumor suppressor
ASJC Scopus subject areas
- Oncology
- Urology