DNA methylation, molecular genetic, and linkage studies in prostate cancer

David F. Jarrard; G. Steven Bova; William B. Isaacs

doi:10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co;2-i

DNA methylation, molecular genetic, and linkage studies in prostate cancer

David F. Jarrard, G. Steven Bova, William B. Isaacs

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation. DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.

Original language	English (US)
Pages (from-to)	36-44
Number of pages	9
Journal	Prostate
Volume	28
Issue number	3 SUPPL. 6
DOIs	https://doi.org/10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co;2-i
State	Published - Jan 1 1996

Keywords

DNA methylation
linkage analysis
prostate cancer
tumor suppressor

ASJC Scopus subject areas

Oncology
Urology

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10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co;2-i

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AB - Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation. DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.

KW - DNA methylation

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KW - prostate cancer

KW - tumor suppressor

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DNA methylation, molecular genetic, and linkage studies in prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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