DNA methylation, molecular genetic, and linkage studies in prostate cancer.

D. F. Jarrard, G. S. Bova, William B Isaacs

Research output: Contribution to journalArticle

Abstract

Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalThe Prostate. Supplement
Volume6
StatePublished - 1996

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Genetic Linkage
DNA Methylation
Molecular Biology
Prostatic Neoplasms
Sequence Deletion
Tumor Suppressor Genes
Point Mutation
Epigenomics
Genes
DNA
Growth
Neoplasms

Cite this

DNA methylation, molecular genetic, and linkage studies in prostate cancer. / Jarrard, D. F.; Bova, G. S.; Isaacs, William B.

In: The Prostate. Supplement, Vol. 6, 1996, p. 36-44.

Research output: Contribution to journalArticle

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