DNA methylation in zebrafish

Mary G. Goll, Marnie E. Halpern

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA methylation is crucial for normal development and cellular differentiation in many large-genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently emerged as a powerful system for the study of DNA methylation, especially in the context of development. This review summarizes our current knowledge of DNA methylation in zebrafish and provides evidence for the general conservation of this system with mammals. In addition, emerging strategies are highlighted that use the fish model to address some of the key unanswered questions in DNA methylation research.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages193-218
Number of pages26
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume101
ISSN (Print)1877-1173

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Goll, M. G., & Halpern, M. E. (2011). DNA methylation in zebrafish. In Progress in Molecular Biology and Translational Science (pp. 193-218). (Progress in Molecular Biology and Translational Science; Vol. 101). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-387685-0.00005-6