DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms

Andrew P. Feinberg; Hengmi Cui; Rolf Ohlsson

doi:10.1016/S1044-579X(02)00059-7

DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms

Andrew P. Feinberg, Hengmi Cui, Rolf Ohlsson

School of Medicine

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.

Original language	English (US)
Pages (from-to)	389-398
Number of pages	10
Journal	Seminars in Cancer Biology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S1044-579X(02)00059-7
State	Published - 2002

Keywords

DNA methylation
Epigenetics
Genomic imprinting

ASJC Scopus subject areas

Cancer Research

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10.1016/S1044-579X(02)00059-7

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title = "DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms",

abstract = "Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.",

keywords = "DNA methylation, Epigenetics, Genomic imprinting",

author = "Feinberg, {Andrew P.} and Hengmi Cui and Rolf Ohlsson",

note = "Funding Information: This work was supported by NIH grant CA65145 (APF) and grants from Swedish Cancer Foundation, Pediatric Cancer Foundation and Lundsberg Foundation (RO). We thank Melinda Graber for preparing the manuscript. ",

year = "2002",

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T2 - Insights from cancer into epigenetic mechanisms

AU - Feinberg, Andrew P.

AU - Cui, Hengmi

AU - Ohlsson, Rolf

N1 - Funding Information: This work was supported by NIH grant CA65145 (APF) and grants from Swedish Cancer Foundation, Pediatric Cancer Foundation and Lundsberg Foundation (RO). We thank Melinda Graber for preparing the manuscript.

PY - 2002

Y1 - 2002

N2 - Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.

AB - Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.

KW - DNA methylation

KW - Epigenetics

KW - Genomic imprinting

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ER -

DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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