DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms

Andrew P. Feinberg, Hengmi Cui, Rolf Ohlsson

Research output: Contribution to journalArticle

Abstract

Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalSeminars in Cancer Biology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 2002

Keywords

  • DNA methylation
  • Epigenetics
  • Genomic imprinting

ASJC Scopus subject areas

  • Cancer Research

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