DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2

Kelly M. McGarvey, Eriko Greene, Jill A. Fahrner, Thomas Jenuwein, Stephen B. Baylin

Research output: Contribution to journalArticlepeer-review

Abstract

Recent work suggests a link between the polycomb group protein EZH2 and mediation of gene silencing in association with maintenance of DNA methylation. However,we show that whereas basally expressed target cancer genes with minimal DNA methylation have increased transcription during EZH2 knockdown,densely DNA hypermethylated and silenced genes retain their methylation and remain transcriptionally silent. These results suggest that EZH2 can modulate transcription of basally expressed genes but not silent genes that are densely DNA methylated.

Original languageEnglish (US)
Pages (from-to)5097-5102
Number of pages6
JournalCancer Research
Volume67
Issue number11
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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