DNA hybridization to oligonucleotide microchip. Correlations and screening for errors

A. V. Favorov, M. A. Livshits, A. D. Mirzabekov

Research output: Contribution to journalArticlepeer-review

Abstract

Here we propose an algorithm for mathematical processing of the primary data on DNA hybridization on an oligonucleotide microchip, obviating most false positives. Such errors are revealed by the absence of the corresponding overlapping oligonucleotide signals. The screen efficiency depending on the length of oligonucleotide and DNA probe as well as the initial number of false positives was evaluated in theory and by computer simulation.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalMolecular Biology
Volume33
Issue number3
StatePublished - May 1 1999
Externally publishedYes

Keywords

  • DNA sequencing
  • Errors
  • Hybridization
  • Oligonucleotides

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

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