DNA damage signaling downstream of ATM

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

ATM is the apical signaling molecule that triggers diverse cellular responses to double-strand DNA breaks. Directly and indirectly, ATM initiates a two-tiered cascade of protein kinase activation, composed of upstream phosphatidylinositol 3-kinase-like kinases, mediator proteins, and checkpoint kinases. Together, these proteins signal a broad network of downstream effectors that modulate virtually every aspect of cell growth and death. This review will focus on the signaling molecules required for the diverse ATM-dependent responses to DNA damage, with an emphasis on the extensively characterized pathways that suppress proliferation and promote DNA repair.

Original languageEnglish (US)
Title of host publicationMolecular Determinants of Radiation Response
EditorsTheodore DeWeese
Pages35-52
Number of pages18
DOIs
StatePublished - Dec 1 2011

Publication series

NameCurrent Cancer Research
Volume19
ISSN (Print)0940-0745

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Keywords

  • ATM
  • ATR
  • Checkpoints
  • DNA damage
  • Signaling network

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bunz, F. (2011). DNA damage signaling downstream of ATM. In T. DeWeese (Ed.), Molecular Determinants of Radiation Response (pp. 35-52). (Current Cancer Research; Vol. 19). https://doi.org/10.1007/978-1-4419-8044-1_2