DNA base excision repair activities in mouse models of Alzheimer's disease

Lior Weissman; Nadja C. de Souza-Pinto; Mark P. Mattson; Vilhelm A. Bohr

doi:10.1016/j.neurobiolaging.2008.02.014

DNA base excision repair activities in mouse models of Alzheimer's disease

Lior Weissman, Nadja C. de Souza-Pinto, Mark P. Mattson, Vilhelm A. Bohr

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.

Original language	English (US)
Pages (from-to)	2080-2081
Number of pages	2
Journal	Neurobiology of Aging
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.02.014
State	Published - Dec 2009
Externally published	Yes

Keywords

Alzheimer's disease
DNA repair
Oxidative DNA damage
Oxidative stress

ASJC Scopus subject areas

Clinical Neurology
General Neuroscience
Aging
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2008.02.014

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title = "DNA base excision repair activities in mouse models of Alzheimer's disease",

abstract = "Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.",

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AU - de Souza-Pinto, Nadja C.

AU - Mattson, Mark P.

AU - Bohr, Vilhelm A.

PY - 2009/12

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AB - Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.

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KW - DNA repair

KW - Oxidative DNA damage

KW - Oxidative stress

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DNA base excision repair activities in mouse models of Alzheimer's disease

Abstract

Keywords

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