DNA Analysis of cardiac myxomas: Flow cytometry and image analysis

Jeffrey D. Seidman; Jules J. Berman; Charles L. Hitchcock; Robert L. Becker; Wolfgang Mergner; G. William Moore; Renu Virmani; Robert A. Yetter

doi:10.1016/0046-8177(91)90137-E

DNA Analysis of cardiac myxomas: Flow cytometry and image analysis

Jeffrey D. Seidman, Jules J. Berman, Charles L. Hitchcock, Robert L. Becker, Wolfgang Mergner, G. William Moore, Renu Virmani, Robert A. Yetter

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2 M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.

Original language	English (US)
Pages (from-to)	494-500
Number of pages	7
Journal	Human Pathology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/0046-8177(91)90137-E
State	Published - 1991

Keywords

aneuploidy
cardiac neoplasms
flow cytometry
image analysis
myxoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/0046-8177(91)90137-E

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title = "DNA Analysis of cardiac myxomas: Flow cytometry and image analysis",

abstract = "Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2 M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.",

keywords = "aneuploidy, cardiac neoplasms, flow cytometry, image analysis, myxoma",

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T2 - Flow cytometry and image analysis

AU - Seidman, Jeffrey D.

AU - Berman, Jules J.

AU - Hitchcock, Charles L.

AU - Becker, Robert L.

AU - Mergner, Wolfgang

AU - William Moore, G.

AU - Virmani, Renu

AU - Yetter, Robert A.

PY - 1991

Y1 - 1991

N2 - Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2 M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.

AB - Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2 M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.

KW - aneuploidy

KW - cardiac neoplasms

KW - flow cytometry

KW - image analysis

KW - myxoma

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ER -

DNA Analysis of cardiac myxomas: Flow cytometry and image analysis

Abstract

Keywords

ASJC Scopus subject areas

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