DNA Analysis of cardiac myxomas: Flow cytometry and image analysis

Jeffrey D. Seidman, Jules J. Berman, Charles L. Hitchcock, Robert L. Becker, Wolfgang Mergner, G. William Moore, Renu Virmani, Robert A. Yetter

    Research output: Contribution to journalArticle

    Abstract

    Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2 M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.

    Original languageEnglish (US)
    Pages (from-to)494-500
    Number of pages7
    JournalHuman Pathology
    Volume22
    Issue number5
    DOIs
    StatePublished - 1991

    Keywords

    • aneuploidy
    • cardiac neoplasms
    • flow cytometry
    • image analysis
    • myxoma

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

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  • Cite this

    Seidman, J. D., Berman, J. J., Hitchcock, C. L., Becker, R. L., Mergner, W., William Moore, G., Virmani, R., & Yetter, R. A. (1991). DNA Analysis of cardiac myxomas: Flow cytometry and image analysis. Human Pathology, 22(5), 494-500. https://doi.org/10.1016/0046-8177(91)90137-E