DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly

Byram H. Ozer, Bernd Smarsly, Markus Antonietti, Charl F.J. Faul

Research output: Contribution to journalArticlepeer-review

Abstract

Here we show that ionic self-assembly of simple biological tectons can be used to synthesize stable and highly ordered molecular structures. In particular, nucleotides and charged polypeptides can be assembled to form a complex analogous to DNA under relatively benign conditions. The combination of polylysine and pure dGMP leads to a fourfold ladder structure stabilizing an interior G-quartet structure by four polypeptide scaffolds. Making use of the Watson-Crick G:C base pairing motive leads to double-stranded complexes. Interestingly, these complexes show stable DNA-like organization in aqueous solutions, as proven by gel electrophoresis and intercalation experiments.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalSoft Matter
Volume2
Issue number4
DOIs
StatePublished - Apr 3 2006
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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