DJ-1 is essential for long-term depression at hippocampal CA1 synapses

Yue Wang, Jayanth S. Chandran, Huaibin Cai, Mark P. Mattson

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalNeuromolecular medicine
Volume10
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • DJ-1
  • Dopamine receptor
  • Hippocampal CA1
  • LTD
  • LTP
  • Parkinson's disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

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