DJ-1 is essential for long-term depression at hippocampal CA1 synapses

Yue Wang; Jayanth S. Chandran; Huaibin Cai; Mark P. Mattson

doi:10.1007/s12017-008-8023-4

DJ-1 is essential for long-term depression at hippocampal CA1 synapses

Yue Wang, Jayanth S. Chandran, Huaibin Cai, Mark P. Mattson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

Original language	English (US)
Pages (from-to)	40-45
Number of pages	6
Journal	Neuromolecular medicine
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/s12017-008-8023-4
State	Published - Mar 2008
Externally published	Yes

Keywords

DJ-1
Dopamine receptor
Hippocampal CA1
LTD
LTP
Parkinson's disease

ASJC Scopus subject areas

Molecular Medicine
Neurology
Cellular and Molecular Neuroscience

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10.1007/s12017-008-8023-4

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title = "DJ-1 is essential for long-term depression at hippocampal CA1 synapses",

abstract = "Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.",

keywords = "DJ-1, Dopamine receptor, Hippocampal CA1, LTD, LTP, Parkinson's disease",

author = "Yue Wang and Chandran, {Jayanth S.} and Huaibin Cai and Mattson, {Mark P.}",

note = "Funding Information: Acknowledgments This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. We thank the Comparative Medicine Section of NIA for technical support. The authors declare that they have no competing financial interest.",

year = "2008",

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doi = "10.1007/s12017-008-8023-4",

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T1 - DJ-1 is essential for long-term depression at hippocampal CA1 synapses

AU - Wang, Yue

AU - Chandran, Jayanth S.

AU - Cai, Huaibin

AU - Mattson, Mark P.

N1 - Funding Information: Acknowledgments This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. We thank the Comparative Medicine Section of NIA for technical support. The authors declare that they have no competing financial interest.

PY - 2008/3

Y1 - 2008/3

N2 - Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

AB - Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

KW - DJ-1

KW - Dopamine receptor

KW - Hippocampal CA1

KW - LTD

KW - LTP

KW - Parkinson's disease

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DJ-1 is essential for long-term depression at hippocampal CA1 synapses

Abstract

Keywords

ASJC Scopus subject areas

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