DJ-1 is essential for long-term depression at hippocampal CA1 synapses

Yue Wang, Jayanth S. Chandran, Huaibin Cai, Mark P. Mattson

    Research output: Contribution to journalArticle

    Abstract

    Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1-/- mice, whereas DJ-1+/- mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

    Original languageEnglish (US)
    Pages (from-to)40-45
    Number of pages6
    JournalNeuromolecular medicine
    Volume10
    Issue number1
    DOIs
    StatePublished - Mar 1 2008

    Keywords

    • DJ-1
    • Dopamine receptor
    • Hippocampal CA1
    • LTD
    • LTP
    • Parkinson's disease

    ASJC Scopus subject areas

    • Molecular Medicine
    • Neurology
    • Cellular and Molecular Neuroscience

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