DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells

Haigang Ren, Kai Fu, Chenchen Mu, Bin Li, Dan Wang, Guanghui Wang

Research output: Contribution to journalArticle

Abstract

Autophagy mediates cellular self-digestion to degrade cytoplasmic proteins and organelles and plays important roles in tumorigenesis. DJ-1 is an oncogene product in association with cancers and tumorigenesis. In this study, we show that knockdown of DJ-1 induces autophagy through activating JNK pathway to promote Beclin 1 transcription, whereas overexpression of DJ-1 inhibits these processes. Moreover, inhibition of JNK pathway by SP600125 blocks autophagy activation and p62 degradation induced by knockdown of DJ-1. Our findings suggest that DJ-1 regulates autophagy in a JNK-dependent manner. Thus, the involvement of DJ-1 in autophagy regulation may be involved in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalCancer Letters
Volume297
Issue number1
DOIs
Publication statusPublished - Nov 1 2010
Externally publishedYes

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Keywords

  • Autophagy
  • Beclin 1
  • DJ-1
  • JNK
  • Tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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