Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: Progress and controversies

William E. Sonntag, Anna Csiszar, Raphael De Cabo, Luigi Ferrucci, Zoltan Ungvari

Research output: Contribution to journalArticlepeer-review

Abstract

Because the initial reports demonstrating that circulating growth hormone and insulin-like growth factor-1 decrease with age in laboratory animals and humans, there have been numerous studies related to the importance of these hormones for healthy aging. Nevertheless, the role of these potent anabolic hormones in the genesis of the aging phenotype remains controversial. In this chapter, we review the studies demonstrating the beneficial and deleterious effects of growth hormone and insulin-like growth factor-1 deficiency and explore their effects on specific tissues and pathology as well as their potentially unique effects early during development. Based on this review, we conclude that the perceived contradictory roles of growth hormone and insulin-like growth factor-1 in the genesis of the aging phenotype should not be interpreted as a controversy on whether growth hormone or insulin-like growth factor-1 increases or decreases life span but rather as an opportunity to explore the complex roles of these hormones during specific stages of the life span.

Original languageEnglish (US)
Pages (from-to)587-598
Number of pages12
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Growth hormone
  • IGF-1
  • Longevity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

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