Diverse Effect of Inflammatory Markers on Insulin Resistance and Insulin-Resistance Syndrome in the Elderly

Angela M. Abbatecola, Luigi Ferrucci, Rodolfo Grella, Stefania Bandinelli, Massimiliano Bonafè, Michelangela Barbieri, Anna M. Corsi, Fulvio Lauretani, Claudio Franceschi, Giuseppe Paolisso

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To evaluate the potential association between different inflammatory markers and insulin resistance (IR), as well as insulin-resistance syndrome (IRS) in a large, population-based study of older, nondiabetic persons. DESIGN: Cross-sectional study. SETTING: Outpatient clinic in Greve in Chianti and Bagao a Ripoli (Italy). PARTICIPANTS: One thousand one hundred forty-six nondiabetic subjects ranging in age from 22 to 104. MEASUREMENTS: Anthropometric measurements; plasma fasting levels of glucose, insulin, and cholesterol (total, high-density lipoprotein, low-density lipoprotein); homeostasis model assessment to estimate degree of insulin resistance; tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), soluble IL-6 receptor (sIL-6R), interleukin receptor antagonist (IL-1ra), and C-reactive protein (CRP) plasma concentrations; diastolic, systolic, and mean arterial blood pressure; and echo-color-Doppler duplex scanning examination of carotid arteries. RESULTS: Insulin resistance correlated with age (r = 0.102; P

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalJournal of the American Geriatrics Society
Volume52
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Keywords

  • Aging
  • InCHIANTI
  • Inflammatory markers
  • Insulin resistance
  • Insulin-resistance syndrome

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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