Divergent roles of autophagy in virus infection

Abhilash I. Chiramel, Nathan R. Brady, Ralf Bartenschlager

Research output: Contribution to journalReview articlepeer-review

Abstract

Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.

Original languageEnglish (US)
Pages (from-to)83-104
Number of pages22
JournalCells
Volume2
Issue number1
DOIs
StatePublished - Jan 25 2013
Externally publishedYes

Keywords

  • Antiviral and proviral autophagy
  • Selectively autophagy
  • Virophagy

ASJC Scopus subject areas

  • Medicine(all)

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