Diurnal variation of air and helium-oxygen flow-volume curves in asthmatic children

Hailen Mak; Bradley E. Chipps; Harold A. Menkes; Kenneth C. Schuberth; Jonathan H. Talamo; Merle S. Scherr; Richard C. Talamo; Solbert Permutt

doi:10.1016/0007-0971(82)90007-9

Diurnal variation of air and helium-oxygen flow-volume curves in asthmatic children

Hailen Mak, Bradley E. Chipps, Harold A. Menkes, Kenneth C. Schuberth, Jonathan H. Talamo, Merle S. Scherr, Richard C. Talamo, Solbert Permutt

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.

Original language	English (US)
Pages (from-to)	51-56
Number of pages	6
Journal	British Journal of Diseases of the Chest
Volume	76
Issue number	C
DOIs	https://doi.org/10.1016/0007-0971(82)90007-9
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/0007-0971(82)90007-9

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@article{cb34dc7be3fe4da3a5c73a00b0499283,

title = "Diurnal variation of air and helium-oxygen flow-volume curves in asthmatic children",

abstract = "In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.",

author = "Hailen Mak and Chipps, {Bradley E.} and Menkes, {Harold A.} and Schuberth, {Kenneth C.} and Talamo, {Jonathan H.} and Scherr, {Merle S.} and Talamo, {Richard C.} and Solbert Permutt",

note = "Funding Information: The project was supported in part by The Hospital for Consumptives of Maryland (Eudowood) and a Johns Hopkins University Institutional Research Grant. Syva (Palo Alto, CA) kindly donated the EMIT@ Theophylline Assay System and supplies for the summer. Dr John Tourville of the University of West Virginia Medical School supervised the theophylline determinations. Louis Wilkinson provided invaluable technical assistance in the collection and analysis of pulmonary function data. Finally, we want to thank Dr Dennis Stokes for reviewing the manuscript and for providing us with helpful suggestions.",

year = "1982",

doi = "10.1016/0007-0971(82)90007-9",

language = "English (US)",

volume = "76",

pages = "51--56",

journal = "British Journal of Diseases of the Chest",

issn = "0007-0971",

publisher = "W.B. Saunders Ltd",

number = "C",

}

TY - JOUR

T1 - Diurnal variation of air and helium-oxygen flow-volume curves in asthmatic children

AU - Mak, Hailen

AU - Chipps, Bradley E.

AU - Menkes, Harold A.

AU - Schuberth, Kenneth C.

AU - Talamo, Jonathan H.

AU - Scherr, Merle S.

AU - Talamo, Richard C.

AU - Permutt, Solbert

N1 - Funding Information: The project was supported in part by The Hospital for Consumptives of Maryland (Eudowood) and a Johns Hopkins University Institutional Research Grant. Syva (Palo Alto, CA) kindly donated the EMIT@ Theophylline Assay System and supplies for the summer. Dr John Tourville of the University of West Virginia Medical School supervised the theophylline determinations. Louis Wilkinson provided invaluable technical assistance in the collection and analysis of pulmonary function data. Finally, we want to thank Dr Dennis Stokes for reviewing the manuscript and for providing us with helpful suggestions.

PY - 1982

Y1 - 1982

N2 - In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.

AB - In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obtained in the morning and afternoon over a 10-day period. We found that significant increases in maximal expiratory flows at all lung volumes occurred in the afternoon. However, the increase in flows with helium (helium response) was unchanged from morning to afternoon. These results suggest that both large and small airways are involved in the diurnal variation of pulmonary function in asthmatic children.

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AN - SCOPUS:0020052166

SN - 0007-0971

VL - 76

SP - 51

EP - 56

JO - British Journal of Diseases of the Chest

JF - British Journal of Diseases of the Chest

IS - C

ER -

Diurnal variation of air and helium-oxygen flow-volume curves in asthmatic children

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