Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

G. J. Peters, J. Van Dijk, J. C. Nadal, C. J. Van Groeningen, J. Lankelma, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

Mice bearing the murine colon carconomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5FU against murine colon cancer is higher when 5FU is administered at 08.30 hr.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalIn vivo (Athens, Greece)
Volume1
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Peters, G. J., Van Dijk, J., Nadal, J. C., Van Groeningen, C. J., Lankelma, J., & Pinedo, H. M. (1987). Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer. In vivo (Athens, Greece), 1(2), 113-118.