Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study

Sevil Yasar, Fu Mei Lin, Linda P Fried, Claudia H. Kawas, Kaycee M. Sink, Steven T. Dekosky, Michelle C Carlson

Research output: Contribution to journalArticle

Abstract

Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function. Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function. Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P =.01; β = 0.094, P

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalAlzheimer's and Dementia
Volume8
Issue number3
DOIs
StatePublished - May 2012

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Verbal Learning
Ginkgo biloba
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Cognition
Antihypertensive Agents
Potassium Sparing Diuretics
Learning
Independent Living
Angiotensin Receptor Antagonists
Linear Models
Regression Analysis
Hypertension
angiotensin converting enzyme 2

Keywords

  • Angiotensin receptor blocker
  • Angiotensin-converting enzyme inhibitor
  • Cognitive function
  • Diuretic

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study. / Yasar, Sevil; Lin, Fu Mei; Fried, Linda P; Kawas, Claudia H.; Sink, Kaycee M.; Dekosky, Steven T.; Carlson, Michelle C.

In: Alzheimer's and Dementia, Vol. 8, No. 3, 05.2012, p. 188-195.

Research output: Contribution to journalArticle

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