TY - JOUR
T1 - Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study
AU - Yasar, Sevil
AU - Lin, Fu Mei
AU - Fried, Linda P.
AU - Kawas, Claudia H.
AU - Sink, Kaycee M.
AU - Dekosky, Steven T.
AU - Carlson, Michelle C.
N1 - Funding Information:
The Ginkgo Evaluation of Memory (GEM) Study was supported by U01 AT000162 from the NCCAM and the Office of Dietary Supplements, and support from the National Institute on Aging, National Heart, Lung, and Blood Institute, the University of Pittsburgh Alzheimer’s Disease Research Center ( P50AG05133 ), the Roena Kulynych Center for Memory and Cognition Research, and National Institute of Neurological Disorders and Stroke. Dr. Yasar is supported by the John A. Hartford Foundation, with grants from NCCAM/NIH ( 1U01AT00016207 ) and NIA/NIH ( T32 AG000247 ).
PY - 2012/5
Y1 - 2012/5
N2 - Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function. Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function. Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P =.01; β = 0.094, P <.001) and other antihypertensive medication users (β = 0.080, P =.03; β = 0.153, P <.001). Use of ACE-I or AT2RB was not associated with better cognitive function. Conclusion: Results warrant further investigation into possible protective effects of potassium-sparing diuretics and the role of potassium in mitigating cognitive decline.
AB - Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function. Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function. Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P =.01; β = 0.094, P <.001) and other antihypertensive medication users (β = 0.080, P =.03; β = 0.153, P <.001). Use of ACE-I or AT2RB was not associated with better cognitive function. Conclusion: Results warrant further investigation into possible protective effects of potassium-sparing diuretics and the role of potassium in mitigating cognitive decline.
KW - Angiotensin receptor blocker
KW - Angiotensin-converting enzyme inhibitor
KW - Cognitive function
KW - Diuretic
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U2 - 10.1016/j.jalz.2011.03.010
DO - 10.1016/j.jalz.2011.03.010
M3 - Article
C2 - 22465175
AN - SCOPUS:84860494623
SN - 1552-5260
VL - 8
SP - 188
EP - 195
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 3
ER -