Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study

Sevil Yasar, Fu Mei Lin, Linda P. Fried, Claudia H. Kawas, Kaycee M. Sink, Steven T. Dekosky, Michelle C. Carlson

Research output: Contribution to journalArticle

Abstract

Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function. Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function. Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P =.01; β = 0.094, P <.001) and other antihypertensive medication users (β = 0.080, P =.03; β = 0.153, P <.001). Use of ACE-I or AT2RB was not associated with better cognitive function. Conclusion: Results warrant further investigation into possible protective effects of potassium-sparing diuretics and the role of potassium in mitigating cognitive decline.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalAlzheimer's and Dementia
Volume8
Issue number3
DOIs
StatePublished - May 1 2012

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Keywords

  • Angiotensin receptor blocker
  • Angiotensin-converting enzyme inhibitor
  • Cognitive function
  • Diuretic

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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