TY - JOUR
T1 - Disturbed sleep and diabetes
T2 - A potential nexus of dementia risk
AU - Holingue, Calliope
AU - Wennberg, Alexandra
AU - Berger, Slava
AU - Polotsky, Vsevolod Y.
AU - Spira, Adam P.
N1 - Funding Information:
Adam Spira agreed to serve as a consultant to Awarables, Inc. in support of an NIH grant. All other authors confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Funding Information:
Adam Spira is supported in part by National Institute on Aging grants AG050507 , AG050745 , AG052445 , and AG049872 .
Funding Information:
Calliope Holingue is supported by the NIMH Psychiatric Epidemiology Training Program ( 5T32MH014592-39 ; PI: Zandi, Peter).
Publisher Copyright:
© 2018
PY - 2018/7
Y1 - 2018/7
N2 - Type 2 diabetes (T2D) and sleep disturbance (e.g., insomnia, sleep-disordered breathing) are prevalent conditions among older adults that are associated with cognitive decline and dementia, including Alzheimer's disease (AD). Importantly, disturbed sleep is associated with alterations in insulin sensitivity and glucose metabolism, and may increase the risk of T2D, and T2D-related complications (e.g., pain, nocturia) can negatively affect sleep. Despite these associations, little is known about how interactions between T2D and sleep disturbance might alter cognitive trajectories or the pathological changes that underlie dementia. Here, we review links among T2D, sleep disturbance, cognitive decline and dementia—including preclinical and clinical AD—and identify gaps in the literature, that if addressed, could have significant implications for the prevention of poor cognitive outcomes.
AB - Type 2 diabetes (T2D) and sleep disturbance (e.g., insomnia, sleep-disordered breathing) are prevalent conditions among older adults that are associated with cognitive decline and dementia, including Alzheimer's disease (AD). Importantly, disturbed sleep is associated with alterations in insulin sensitivity and glucose metabolism, and may increase the risk of T2D, and T2D-related complications (e.g., pain, nocturia) can negatively affect sleep. Despite these associations, little is known about how interactions between T2D and sleep disturbance might alter cognitive trajectories or the pathological changes that underlie dementia. Here, we review links among T2D, sleep disturbance, cognitive decline and dementia—including preclinical and clinical AD—and identify gaps in the literature, that if addressed, could have significant implications for the prevention of poor cognitive outcomes.
KW - Alzheimer's disease
KW - Cognition
KW - Diabetes
KW - Sleep
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U2 - 10.1016/j.metabol.2018.01.021
DO - 10.1016/j.metabol.2018.01.021
M3 - Article
C2 - 29409842
AN - SCOPUS:85042448178
SN - 0026-0495
VL - 84
SP - 85
EP - 93
JO - Metabolism: clinical and experimental
JF - Metabolism: clinical and experimental
ER -