Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia

Dietmar Bengel, Ursula Balling, Gerald Stöber, Armin Heils, Shi Hua Li, Cristopher A. Ross, Gerd Jungkunz, Ernst Franzek, Helmut Beckmann, Peter Riederer, Klaus Peter Lesch

Research output: Contribution to journalArticle

Abstract

Clinical evidence for a dominant mode of inheritance and anticipation in periodic catatonia, a distinct subtype of schizophrenia, suggests that trinucleotide repeat expansions may be involved in the aetiology of this disorder. Since genes with triplet repeats are putative canditates for causing schizophrenia, we have analysed the polymorphic B33 CTG repeat locus on chromosome 3 in 45 patients with periodic catatonia and 43 control subjects. The B33 CTG repeat locus was highly polymorphic, but all alleles in both the patient and control groups had repeat lengths within the normal range. We conclude that susceptibility to periodic catatonia is not influenced by variation at the B33 CTG repeat locus. Nevertheless, that periodic catatonia displays dominant inheritance and anticipation, characteristic of genetic disorders involving trinucleotide repeats, justifies further screening for triplet repeat expansions in this illness.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume248
Issue number2
DOIs
StatePublished - Apr 1998

Keywords

  • Anticipation
  • Association study
  • B33 CTG repeat locus
  • Periodic catatonia
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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  • Cite this

    Bengel, D., Balling, U., Stöber, G., Heils, A., Li, S. H., Ross, C. A., Jungkunz, G., Franzek, E., Beckmann, H., Riederer, P., & Lesch, K. P. (1998). Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 248(2), 78-81. https://doi.org/10.1007/s004060050021