Distribution of lymphocytes in persons with Alzheimer's disease (AD) as compared to age matched nondemented (ND) control subjects

Rekha Sharma, J. W. Chiao, Karen Turo, Ronald Ammon, Jeffrey E. Escher, Steven R. Gambert

Research output: Contribution to journalArticle

Abstract

Persons with Alzheimer's disease have been noted to have an increased number of infections and a possible change in immune system function has been suggested. This study analyzed immune cell subtypes in persons with Alzheimer's disease compared to age matched nondemented controls. We analyzed the number and proportion of total T cells (CD3), T helper cells (CD4), T suppressor cells (CD8), B cells (CD19), and Natural Killer cells (CD56) in the peripheral blood of eleven patients with Alzheimer's dementia and six controls. A statistically significant decrease in the number of B cells (CDI9) was identified in persons with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalClinical Gerontologist
Volume18
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

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dementia
Alzheimer Disease
Lymphocytes
human being
B-Lymphocytes
helper
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Immune System
T-Lymphocytes
Infection

ASJC Scopus subject areas

  • Aging

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Distribution of lymphocytes in persons with Alzheimer's disease (AD) as compared to age matched nondemented (ND) control subjects. / Sharma, Rekha; Chiao, J. W.; Turo, Karen; Ammon, Ronald; Escher, Jeffrey E.; Gambert, Steven R.

In: Clinical Gerontologist, Vol. 18, No. 2, 1997, p. 13-19.

Research output: Contribution to journalArticle

Sharma, Rekha ; Chiao, J. W. ; Turo, Karen ; Ammon, Ronald ; Escher, Jeffrey E. ; Gambert, Steven R. / Distribution of lymphocytes in persons with Alzheimer's disease (AD) as compared to age matched nondemented (ND) control subjects. In: Clinical Gerontologist. 1997 ; Vol. 18, No. 2. pp. 13-19.
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