Distribution of cardiovascular related cells within the human thalamus

S. M. Oppenheimer, N. Kulshreshtha, Frederick Lenz, Zhihua Zhang, L. H. Rowland, P. M. Dougherty

Research output: Contribution to journalArticle

Abstract

Representation of cardiovascular function has not been investigated in the human thalamus. In the rat, the insular cortex is the principal forebrain site of cardiovascular representation whose afferents originate from a circumscribed thalamic area (nucleus ventralis posterolateralis-parvicellular portion, VPLpc). We therefore evaluated 4481 thalamic cells for phasic cardiovascular activity using extracellular recording techniques in 60 unanesthetized patients undergoing neurosurgical procedures. We identified 26 cells with phasic activity strongly related to the cardiac cycle in 10 patients. These cells clustered within the ventrocaudal nucleus of the thalamus (the principal sensory nucleus analagous to the ventral posterior thalamic group in the rat and monkey) and were equally distributed between the right and left sides. The majority of these cells (17/26) showed peaks of phasic neuronal activity within 50 ms of the peak systolic pressure; 35% had peripheral cutaneous fields in areas to which cardiac pain is often referred. We suggest that these cells may be involved in the integration of afferent baroreceptor information; may possibly be concerned with the generation and/or processing of central cardiac pain in humans; and that their derangement may possibly contribute to the lethal cardiovascular disturbances which occur in fatal familial insomnia.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalClinical Autonomic Research
Volume8
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Thalamus
Fatal Familial Insomnia
Ventral Thalamic Nuclei
Neurosurgical Procedures
Pain
Thalamic Nuclei
Pressoreceptors
Prosencephalon
Cerebral Cortex
Haplorhini
Blood Pressure
Skin

Keywords

  • Autonomic aerents
  • Baroreceptor
  • Blood pressure
  • Cardiac rhythm
  • Insular cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Oppenheimer, S. M., Kulshreshtha, N., Lenz, F., Zhang, Z., Rowland, L. H., & Dougherty, P. M. (1998). Distribution of cardiovascular related cells within the human thalamus. Clinical Autonomic Research, 8(3), 173-179. https://doi.org/10.1007/BF02281122

Distribution of cardiovascular related cells within the human thalamus. / Oppenheimer, S. M.; Kulshreshtha, N.; Lenz, Frederick; Zhang, Zhihua; Rowland, L. H.; Dougherty, P. M.

In: Clinical Autonomic Research, Vol. 8, No. 3, 1998, p. 173-179.

Research output: Contribution to journalArticle

Oppenheimer, SM, Kulshreshtha, N, Lenz, F, Zhang, Z, Rowland, LH & Dougherty, PM 1998, 'Distribution of cardiovascular related cells within the human thalamus', Clinical Autonomic Research, vol. 8, no. 3, pp. 173-179. https://doi.org/10.1007/BF02281122
Oppenheimer, S. M. ; Kulshreshtha, N. ; Lenz, Frederick ; Zhang, Zhihua ; Rowland, L. H. ; Dougherty, P. M. / Distribution of cardiovascular related cells within the human thalamus. In: Clinical Autonomic Research. 1998 ; Vol. 8, No. 3. pp. 173-179.
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