Distribution of antithrombin III and glucosylceramide in human plasma lipoproteins and lipoprotein deficient plasma

Subroto Chatterjee, William R. Bell, Peter O. Kwiterovich

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the distribution of antithrombin-III and glucosylceramide (Glc-Cer) in human plasma, plasma lipoproteins and lipoprotein-deficient plasma. Antithrom bin III activity was measured employing immunochemical and biological assays. Glc-Cer was quantified by gas liquid chromatography (GLC). Whole plasma contained 145 μg antithrombin III/ml plasma, all of which was associated with the lipoprotein-deficient plasma (d>1.25 g/ml). Whereas, most if not all the plasma GlcCer was associated with plasma low density lipoproteins (LDL) (d-1.022-1.055 g/ml) and high density lipoproteins (HDL) (d-1.063-1.25). GlcCer was not found in the lipoprotein-deficient plasma. We conclude that GlcCer on lipoproteins does not contribute to antithrombin III activity. Moreover, the absence of GlcCer in lipoprotein-deficient plasma does not impair antithrombin-III activity.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalLipids
Volume19
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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