Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan

Yuelong Ji, Xiangyi Kong, Guoying Wang, Xiumei Hong, Xin Xu, Zhu Chen, Tami Bartell, Xiping Xu, Genfu Tang, Fanfan Hou, Yong Huo, Xiaobin Wang, Binyan Wang

Research output: Contribution to journalArticle

Abstract

Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)5900-5914
Number of pages15
JournalNutrients
Volume6
Issue number12
DOIs
StatePublished - Dec 18 2014

Fingerprint

homocysteine
Homocysteine
Rural Population
cardiovascular diseases
gender
Cardiovascular Diseases
Age Distribution
metabolic syndrome
Primary Prevention
risk factors
Age Groups
Genotype

Keywords

  • Chinese twins
  • Gender difference
  • Heritability
  • Homocysteine
  • Smoking

ASJC Scopus subject areas

  • Food Science

Cite this

Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan. / Ji, Yuelong; Kong, Xiangyi; Wang, Guoying; Hong, Xiumei; Xu, Xin; Chen, Zhu; Bartell, Tami; Xu, Xiping; Tang, Genfu; Hou, Fanfan; Huo, Yong; Wang, Xiaobin; Wang, Binyan.

In: Nutrients, Vol. 6, No. 12, 18.12.2014, p. 5900-5914.

Research output: Contribution to journalArticle

Ji, Y, Kong, X, Wang, G, Hong, X, Xu, X, Chen, Z, Bartell, T, Xu, X, Tang, G, Hou, F, Huo, Y, Wang, X & Wang, B 2014, 'Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan', Nutrients, vol. 6, no. 12, pp. 5900-5914. https://doi.org/10.3390/nu6125900
Ji, Yuelong ; Kong, Xiangyi ; Wang, Guoying ; Hong, Xiumei ; Xu, Xin ; Chen, Zhu ; Bartell, Tami ; Xu, Xiping ; Tang, Genfu ; Hou, Fanfan ; Huo, Yong ; Wang, Xiaobin ; Wang, Binyan. / Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5900-5914.
@article{13f337acc6324a27bcea7f1c5af24bec,
title = "Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan",
abstract = "Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43{\%} of male adults and 13{\%} of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52{\%}, 36{\%} and 69{\%} of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.",
keywords = "Chinese twins, Gender difference, Heritability, Homocysteine, Smoking",
author = "Yuelong Ji and Xiangyi Kong and Guoying Wang and Xiumei Hong and Xin Xu and Zhu Chen and Tami Bartell and Xiping Xu and Genfu Tang and Fanfan Hou and Yong Huo and Xiaobin Wang and Binyan Wang",
year = "2014",
month = "12",
day = "18",
doi = "10.3390/nu6125900",
language = "English (US)",
volume = "6",
pages = "5900--5914",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",

}

TY - JOUR

T1 - Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan

AU - Ji, Yuelong

AU - Kong, Xiangyi

AU - Wang, Guoying

AU - Hong, Xiumei

AU - Xu, Xin

AU - Chen, Zhu

AU - Bartell, Tami

AU - Xu, Xiping

AU - Tang, Genfu

AU - Hou, Fanfan

AU - Huo, Yong

AU - Wang, Xiaobin

AU - Wang, Binyan

PY - 2014/12/18

Y1 - 2014/12/18

N2 - Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

AB - Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

KW - Chinese twins

KW - Gender difference

KW - Heritability

KW - Homocysteine

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84919460103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919460103&partnerID=8YFLogxK

U2 - 10.3390/nu6125900

DO - 10.3390/nu6125900

M3 - Article

C2 - 25529062

AN - SCOPUS:84919460103

VL - 6

SP - 5900

EP - 5914

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

ER -