Distribution and determinants of pesticide mixtures in cord serum using principal component analysis

Gila Neta, Lynn R. Goldman, Dana Barr, Andreas Sjödin, Benjamin J. Apelberg, Frank R Witter, Rolf U. Halden

Research output: Contribution to journalArticle

Abstract

We characterized the distribution and determinants of fetal exposures to pesticide mixtures using a cross-sectional study of 297 singletons delivered at Johns Hopkins Hospital in Baltimore, MD (2004-2005). Concentrations of nine persistent and twelve nonpersistent pesticides were measured in cord serum. Mixtures were identified using principal components analysis. Associations between mixtures and maternal and infant characteristics were evaluated using multivariate analysis. p,p'-DDE, p,p'-DDT, trans-nonachlor, oxychlordane, bendiocarb, propoxur, and trans- and cis-permethrin were detected in 100, 90, 93, 84, 73, 55, 52, and 41% of serum samples, respectively. There were four independent pesticide components: DDT (p,p'-DDT + p,p'-DDE), chlordane (trans-nonachlor + oxychlordane), permethrin (trans- and cis-permethrins + PBUT), and carbamate (bendiocarb + propoxur). DDT and chlordane were 6.1 (95%CI: 2.4, 15.5) and 2.1 (95%CI: 1.0, 4.2) times higher for infants of women >35, and 1.8 (95%CI: 1.2, 2.9) and 1.5 (95%CI: 1.1, 2.1) times higher in smoking mothers. DDT and carbamate were 15 (95%CI: 7, 30) and 2 (95%CI: 1, 4) times higher for infants of Asian compared with Caucasian mothers. No significant differences were observed for permethrin. Fetal exposures to pesticides are widespread, occur as mixtures, and differ by maternal race, age, and smoking status.

Original languageEnglish (US)
Pages (from-to)5641-5648
Number of pages8
JournalEnvironmental Science and Technology
Volume44
Issue number14
DOIs
StatePublished - Jul 15 2010

Fingerprint

Permethrin
DDT
permethrin
Principal Component Analysis
Pesticides
Principal component analysis
serum
principal component analysis
pesticide
Dichlorodiphenyl Dichloroethylene
Propoxur
Serum
Chlordan
carbamate (ester)
chlordane
DDE
smoking
Carbamates
Mothers
Smoking

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Medicine(all)

Cite this

Distribution and determinants of pesticide mixtures in cord serum using principal component analysis. / Neta, Gila; Goldman, Lynn R.; Barr, Dana; Sjödin, Andreas; Apelberg, Benjamin J.; Witter, Frank R; Halden, Rolf U.

In: Environmental Science and Technology, Vol. 44, No. 14, 15.07.2010, p. 5641-5648.

Research output: Contribution to journalArticle

Neta, Gila ; Goldman, Lynn R. ; Barr, Dana ; Sjödin, Andreas ; Apelberg, Benjamin J. ; Witter, Frank R ; Halden, Rolf U. / Distribution and determinants of pesticide mixtures in cord serum using principal component analysis. In: Environmental Science and Technology. 2010 ; Vol. 44, No. 14. pp. 5641-5648.
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