Distribution analysis of alveolar size by digital imaging

Y. I. Huang, Wayne Mitzner

Research output: Contribution to journalArticlepeer-review


To estimate the size distribution of the alveoli of the lung, an automated method has been developed by using a digital imaging technique, which acquires, processes, converts, and edits lung histologic images from the microscope. The binary images are analyzed by measuring the spacing between alveolar walls along a grid of parallel lines. The resultant intercept data are fit with a bimodal distribution consisting of two lognormal distributions. We were thus able to distinguish the smaller distribution that is comprised primarily of alveolar intercepts. The effect of the binary image-editing features, and the goodness-of-fit of the distribution curve are discussed. The analysis provides a dimensional improvement compared to the information that is normally obtained from lung histologic sections.

Original languageEnglish (US)
Pages (from-to)397-409
Number of pages13
JournalJournal of Computer-Assisted Microscopy
Issue number4
StatePublished - Dec 1 1989

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials


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