Experimental results characterizing a very-large scale integration (VLSI) potentiostat sensor system for recording distributed neurotransmitter activity are presented. Neurotransmitter concentration is electrochemically transduced using an array of carbon electrodes. The resultant currents are then processed in parallel by eight integrated potentiostat channels consisting of a current amplification stage, current-mode delta-sigma A/D converter, and counting decimator. Electrical characterization has shown that the VLSI potentiostat is sensitive to picoampere levels of input current. Furthermore, both static and dynamic neurochemical measurements of dopamine are verified in vitro, proving the utility of the device for brain slice studies. Lastly, a biologically inspired experiment, whereby the catabolism of dopamine is mimicked with the addition of the COMT enzyme modulate dopamine levels in vitro.
|Original language||English (US)|
|Journal||Proceedings - IEEE International Symposium on Circuits and Systems|
|State||Published - 2003|
|Event||Proceedings of the 2003 IEEE International Symposium on Circuits and Systems - Bangkok, Thailand|
Duration: May 25 2003 → May 28 2003
ASJC Scopus subject areas
- Electrical and Electronic Engineering