Distortion of memory v δ2γδ T cells contributes to immune dysfunction in chronic HIV infection

Zhen Li, Yanmei Jiao, Yu Hu, Lianxian Cui, Dexi Chen, Hao Wu, Jianmin Zhang, Wei He

Research output: Contribution to journalArticlepeer-review

Abstract

γδ T cells play important roles in innate immunity as the first-line of defense against infectious diseases. Human immunodeficiency virus (HIV) infection disrupts the balance between Vδ 1 T cells and Vδ 2 T cells and causes dysfunction among γδ T cells. However, the biological mechanisms and clinical consequences of this disruption require further investigation. In this study, we performed a comprehensive analysis of phenotype and function of memory γδ T cells in cohorts of Chinese individuals with HIV infection. We found a dynamic change in memory Vδ 2 γδ T cells, skewed toward an activated and terminally differentiated effector memory phenotype T EMRA Vδ 2 γδ T cell, which may account for the dysfunction of Vδ 2 γδ T cells in HIV disease. In addition, we found that IL-17-producing γδ T cells were significantly increased in HIV-infected patients with fast disease progression and positively correlated with HLA-DR + γδ T cells and CD38 + HLA-DR + γδ T cells. This suggests the IL-17 signaling pathway is involved in γδ T-cell activation and HIV pathogenesis. Our findings provide novel insights into the role of Vδ 2 T cells during HIV pathogenesis and represent a sound basis on which to consider immune therapies with these cells.

Original languageEnglish (US)
Pages (from-to)604-614
Number of pages11
JournalCellular and Molecular Immunology
Volume12
Issue number5
DOIs
StatePublished - Sep 8 2015
Externally publishedYes

Keywords

  • HIV
  • IL-17
  • immune activation
  • memory V δ<inf>2</inf>γδ T cells
  • γδT cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Fingerprint

Dive into the research topics of 'Distortion of memory v δ<sub>2</sub>γδ T cells contributes to immune dysfunction in chronic HIV infection'. Together they form a unique fingerprint.

Cite this