Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping

Stephen J. Kolb, Fiona Costello, Andrew G. Lee, Matthew White, Stephen Wong, Eric D. Schwartz, Steven R. Messé, Jeffrey Ellenbogen, Scott E. Kasner, Steven L. Galetta

Research output: Contribution to journalArticle

Abstract

We report two patients with migraine, acute visual field defects and other neurological symptoms who were found to have high T2 signal and FLAIR abnormalities on brain MRI in temporal and parieto-occipital regions. In these patients, the apparent diffusion coefficient (ADC) of their lesions was increased, distinguishing these lesions from those of ischemic stroke. Both were ultimately diagnosed with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of the Neurological Sciences
Volume216
Issue number1
DOIs
StatePublished - Dec 15 2003

Keywords

  • Apparent diffusion coefficient
  • MELAS
  • Magnetic resonance imaging
  • Visual loss

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Kolb, S. J., Costello, F., Lee, A. G., White, M., Wong, S., Schwartz, E. D., Messé, S. R., Ellenbogen, J., Kasner, S. E., & Galetta, S. L. (2003). Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping. Journal of the Neurological Sciences, 216(1), 11-15. https://doi.org/10.1016/S0022-510X(03)00218-1