Distinctive immunohistochemical profile of penile intraepithelial lesions

A study of 74 cases

Alcides Chaux, Rolf Pfannl, Ingrid M. Rodríguez, José E. Barreto, Elsa F. Velazquez, Cecilia Lezcano, Adriano Piris, George J. Netto, Antonio L. Cubilla

Research output: Contribution to journalArticle

Abstract

Several classification schemes for penile precancerous lesions have been proposed, but none of them seems to correlate with the current understanding of penile cancer pathogenesis. Recently, a system, which takes into account morphologic features and purported etiopathogenesis, was proposed, separating penile intraepithelial neoplasia (PeIN) in differentiated and warty/basaloid subtypes. This study was designed to seek an immunohistochemical profile that can be helpful in the classification and differential diagnosis of penile epithelial abnormalities and precancerous lesions using the aforementioned system. The immunohistochemical panel included stains for p16, p53, and Ki-67. For p16 immunostaining, only full-thickness positivity in all epithelial cells was considered as positive; for p53 and Ki-67 immunostaining, patchy or diffuse nuclear positivity above the basal layer was considered as positive. Seventy-four lesions in 59 patients were selected and classified as follows: differentiated PeIN, 34 cases; squamous hyperplasia (SH), 21 cases; basaloid PeIN, 15 cases; and warty PeIN, 4 cases. The mean age of patients was 64 years. Forty-two lesions (56.8%) were located in the glans and 32 (43.2%) in the foreskin. Overexpression of p16 was useful for distinguishing SH from warty/basaloid PeINs (0% vs. 94.7%, P

Original languageEnglish (US)
Pages (from-to)553-562
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number4
DOIs
StatePublished - Apr 2011

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Hyperplasia
Neoplasms
Penile Neoplasms
Foreskin
Differential Diagnosis
Coloring Agents
Epithelial Cells

Keywords

  • carcinoma in situ
  • differentiated penile intraepithelial neoplasia
  • Penile intraepithelial neoplasia
  • squamous hyperplasia
  • warty/basaloid penile intraepithelial neoplasia

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Chaux, A., Pfannl, R., Rodríguez, I. M., Barreto, J. E., Velazquez, E. F., Lezcano, C., ... Cubilla, A. L. (2011). Distinctive immunohistochemical profile of penile intraepithelial lesions: A study of 74 cases. American Journal of Surgical Pathology, 35(4), 553-562. https://doi.org/10.1097/PAS.0b013e3182113402

Distinctive immunohistochemical profile of penile intraepithelial lesions : A study of 74 cases. / Chaux, Alcides; Pfannl, Rolf; Rodríguez, Ingrid M.; Barreto, José E.; Velazquez, Elsa F.; Lezcano, Cecilia; Piris, Adriano; Netto, George J.; Cubilla, Antonio L.

In: American Journal of Surgical Pathology, Vol. 35, No. 4, 04.2011, p. 553-562.

Research output: Contribution to journalArticle

Chaux, A, Pfannl, R, Rodríguez, IM, Barreto, JE, Velazquez, EF, Lezcano, C, Piris, A, Netto, GJ & Cubilla, AL 2011, 'Distinctive immunohistochemical profile of penile intraepithelial lesions: A study of 74 cases', American Journal of Surgical Pathology, vol. 35, no. 4, pp. 553-562. https://doi.org/10.1097/PAS.0b013e3182113402
Chaux, Alcides ; Pfannl, Rolf ; Rodríguez, Ingrid M. ; Barreto, José E. ; Velazquez, Elsa F. ; Lezcano, Cecilia ; Piris, Adriano ; Netto, George J. ; Cubilla, Antonio L. / Distinctive immunohistochemical profile of penile intraepithelial lesions : A study of 74 cases. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 4. pp. 553-562.
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