TY - JOUR
T1 - Distinction of isolated tumour cells and micrometastasis in lymph nodes of breast cancer patients according to the new Tumour Node Metastasis (TNM) definitions
AU - Cserni, Gábor
AU - Amendoeira, Isabel
AU - Bianchi, Simonetta
AU - Chmielik, Ewa
AU - Degaetano, James
AU - Faverly, Daniel
AU - Figueiredo, Paulo
AU - Foschini, Maria P.
AU - Grabau, Dorthe
AU - Jacquemier, Jocelyne
AU - Kaya, Handan
AU - Kulka, Janina
AU - Lacerda, Manuela
AU - Liepniece-Karele, Inta
AU - Penuela, Jose Martinez
AU - Quinn, Cecily
AU - Regitnig, Peter
AU - Reiner-Concin, Angelika
AU - Sapino, Anna
AU - Van Diest, Paul J.
AU - Varga, Zsuzsanna
AU - Vezzosi, Vania
AU - Wesseling, Jelle
AU - Zolota, Vasiliki
AU - Zozaya, Enrique
AU - Wells, Clive A.
PY - 2011/4
Y1 - 2011/4
N2 - Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting moderate reproducibility, and the kappa of the micrometastatic category (0.62) reflected substantial reproducibility. This is an improvement over the results gained on the basis of the previous edition of the TNM. Maximal adherence to the category definitions supplemented by explanatory texts in the staging manual should result in more homogeneous nodal staging of breast cancer.
AB - Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting moderate reproducibility, and the kappa of the micrometastatic category (0.62) reflected substantial reproducibility. This is an improvement over the results gained on the basis of the previous edition of the TNM. Maximal adherence to the category definitions supplemented by explanatory texts in the staging manual should result in more homogeneous nodal staging of breast cancer.
KW - Breast cancer
KW - Isolated tumour cell cluster
KW - Isolated tumour cells
KW - Micrometastasis
KW - Sentinel lymph node
KW - TNM
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UR - http://www.scopus.com/inward/citedby.url?scp=79952985420&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2010.11.011
DO - 10.1016/j.ejca.2010.11.011
M3 - Article
C2 - 21168328
AN - SCOPUS:79952985420
VL - 47
SP - 887
EP - 894
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 6
ER -