Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67

Ximing J. Yang, Michael McEntee, Jonathan I. Epstein

Research output: Contribution to journalArticle

Abstract

The distinction of rare basaloid carcinomas (BC) of the prostate from more common basal cell hyperplasia may be difficult, because basal cell hyperplasia (BCH) may have prominent nucleoli and may appear infiltrative. Using immunohistochemistry, we studied bcl-2 and p53 expression and Ki-67 proliferation index in eight cases of typical BCH, eight cases of BCH with nucleoli, and six cases of BC. Bcl-2 expression (P < .0001)and Ki-67 index (P = .005) were elevated in BC compared with typical BCH or BCH with nucleoli, whereas there was no significant difference between typical BCH and BCH with nucleoli. P53 was not discriminative in separating benign from malignant basal cell lesions of the prostate. Bcl-2 may play a role in the pathogenesis of basal cell lesions of the prostate. Elevated expression of bcl-2 and higher Ki-67 index may aid in the diagnosis of basal cell proliferative lesions of the prostate.

Original languageEnglish (US)
Pages (from-to)1447-1450
Number of pages4
JournalHuman pathology
Volume29
Issue number12
DOIs
StatePublished - Jan 1 1998

Keywords

  • Adenoid cystic carcinoma
  • Basal cell hyperplasia
  • Basal cell proliferative lesions
  • Basaloid carcinoma
  • Ki-67
  • Prostate
  • bcl-2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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