Abstract
GABAergic activity is important in neocortical development and plasticity. Because the maturation of GABAergic interneurons is regulated by neural activity, the source of excitatory inputs to GABAergic interneurons plays a key role in development. We show, by laser-scanning photostimulation, that layer 4 and layer 5 GABAergic interneurons in the auditory cortex in neonatal mice (<P7) receive extensive translaminar glutamatergic input via NMDAR-only synapses. Extensive translaminar AMPAR-mediated input developed during the second postnatal week, whereas NMDAR-only presynaptic connections decreased. GABAergic interneurons showed two spatial patterns of translaminar connection: inputs originating predominantly from supragranular or from supragranular and infragranular layers, including the subplate, which relays early thalamocortical activity. Sensory deprivation altered the development of translaminar inputs. Thus, distinct translaminar circuits to GABAergic interneurons exist throughout development, and the maturation of excitatory synapses is input-specific. Glutamatergic signaling from subplate and intracortical sources likely plays a role in the maturation of GABAergic interneurons.
Original language | English (US) |
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Pages (from-to) | 1141-1150 |
Number of pages | 10 |
Journal | Cell Reports |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - May 9 2017 |
Externally published | Yes |
Keywords
- GABA
- NMDA
- auditory cortex
- development
- interneuron
- silent synapse
- subplate
- translaminar
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology