Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity

Kaiwen He, Emily Petrus, Nicholas Gammon, Hey-Kyoung Lee

Research output: Contribution to journalArticle

Abstract

Loss of a sensory modality elicits both unimodal changes in the deprived cortex and cross-modal alterations in the remaining sensory systems. Unimodal changes are proposed to recruit the deprived cortex for processing the remaining senses, while cross-modal changes are thought to refine processing of spared senses. Hence coordinated unimodal and cross-modal changes are likely beneficial. Despite this expectation, we report in mice that losing behaviorally relevant patterned vision is sufficient to trigger cross-modal synaptic changes in the primary somatosensory cortex barrel fields, but is insufficient to drive unimodal synaptic plasticity in visual cortex (V1), which requires a complete loss of visual activity. In addition, cross-modal changes depend on whisker inputs. Our results demonstrate that unimodal and cross-modal synaptic plasticity occur independently of each other and rely on distinct sensory requirements.

Original languageEnglish (US)
Pages (from-to)8469-8474
Number of pages6
JournalJournal of Neuroscience
Volume32
Issue number25
DOIs
StatePublished - Jun 20 2012

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Neuronal Plasticity
Vibrissae
Somatosensory Cortex
Visual Cortex
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ASJC Scopus subject areas

  • Neuroscience(all)

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Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. / He, Kaiwen; Petrus, Emily; Gammon, Nicholas; Lee, Hey-Kyoung.

In: Journal of Neuroscience, Vol. 32, No. 25, 20.06.2012, p. 8469-8474.

Research output: Contribution to journalArticle

He, Kaiwen ; Petrus, Emily ; Gammon, Nicholas ; Lee, Hey-Kyoung. / Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. In: Journal of Neuroscience. 2012 ; Vol. 32, No. 25. pp. 8469-8474.
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