Distinct neural signatures of threat learning in adolescents and adults

Jennifer Y. Lau, Jennifer C. Britton, Eric E. Nelson, Adrian Angold, Monique Ernst, Michelle Goldwin, Christian Grillon, Ellen Leibenluft, Shmuel Lissek, Maxine Norcross, Nina Shiffrin, Daniel S. Pine

Research output: Contribution to journalArticle

Abstract

Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability to form clear-cut threat categories, allowing pervasive fears to manifest. Here we developed a discrimination learning paradigm that assesses the ability to categorize threat from safety cues to test these hypotheses on age differences in neurodevelopment. In experiment 1, we first demonstrated the capacity of this paradigm to generate threat/safety discrimination learning in both adolescents and adults. Next, in experiment 2, we used this paradigm to compare the behavioral and neural correlates of threat/safety discrimination learning in adolescents and adults using functional MRI. This second experiment yielded three sets of findings. First, when labeling threats online, adolescents reported less discrimination between threat and safety cues than adults. Second, adolescents were more likely than adults to engage early-maturing subcortical structures during threat/safety discrimination learning. Third, adults' but not adolescents' engagement of late-maturing prefrontal cortex regions correlated positively with fear ratings during threat/safety discrimination learning. These data are consistent with the role of dorsolateral regions during category learning, particularly when differences between stimuli are subtle [Miller EK, Cohen JD (2001) Annu Rev Neurosci 24:167-202]. These findings suggest that maturational differences in subcortical and prefrontal regions between adolescent and adult brains may relate to age-related differences in threat/safety discrimination.

Original languageEnglish (US)
Pages (from-to)4500-4505
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number11
DOIs
StatePublished - Mar 15 2011
Externally publishedYes

Fingerprint

Discrimination Learning
Learning
Safety
Fear
Aptitude
Prefrontal Cortex
Cues
Brain
Magnetic Resonance Imaging

Keywords

  • Amygdala
  • Anxiety
  • Brain development
  • Discriminative fear conditioning
  • Threat responding

ASJC Scopus subject areas

  • General

Cite this

Lau, J. Y., Britton, J. C., Nelson, E. E., Angold, A., Ernst, M., Goldwin, M., ... Pine, D. S. (2011). Distinct neural signatures of threat learning in adolescents and adults. Proceedings of the National Academy of Sciences of the United States of America, 108(11), 4500-4505. https://doi.org/10.1073/pnas.1005494108

Distinct neural signatures of threat learning in adolescents and adults. / Lau, Jennifer Y.; Britton, Jennifer C.; Nelson, Eric E.; Angold, Adrian; Ernst, Monique; Goldwin, Michelle; Grillon, Christian; Leibenluft, Ellen; Lissek, Shmuel; Norcross, Maxine; Shiffrin, Nina; Pine, Daniel S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 11, 15.03.2011, p. 4500-4505.

Research output: Contribution to journalArticle

Lau, JY, Britton, JC, Nelson, EE, Angold, A, Ernst, M, Goldwin, M, Grillon, C, Leibenluft, E, Lissek, S, Norcross, M, Shiffrin, N & Pine, DS 2011, 'Distinct neural signatures of threat learning in adolescents and adults', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 11, pp. 4500-4505. https://doi.org/10.1073/pnas.1005494108
Lau, Jennifer Y. ; Britton, Jennifer C. ; Nelson, Eric E. ; Angold, Adrian ; Ernst, Monique ; Goldwin, Michelle ; Grillon, Christian ; Leibenluft, Ellen ; Lissek, Shmuel ; Norcross, Maxine ; Shiffrin, Nina ; Pine, Daniel S. / Distinct neural signatures of threat learning in adolescents and adults. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. 11. pp. 4500-4505.
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