Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression

Andreea Oliviana Diaconescu, Elisse Kramer, Carol Hermann, Yilong Ma, Vijay Dhawan, Thomas Chaly, David Eidelberg, Anthony Randal Mcintosh, Gwenn Smith

Research output: Contribution to journalArticle

Abstract

Variability in the affective and cognitive symptom response to antidepressant treatment has been observed in geriatric depression. The underlying neural circuitry is poorly understood. This study evaluated the cerebral glucose metabolic effects of citalopram treatment and applied multivariate, functional connectivity analyses to identify brain networks associated with improvements in affective symptoms and cognitive function. Sixteen geriatric depressed patients underwent resting positron emission tomography (PET) studies of cerebral glucose metabolism and assessment of affective symptoms and cognitive function before and after 8 weeks of selective serotonin reuptake inhibitor treatment (citalopram). Voxel-wise analyses of the normalized glucose metabolic data showed decreased cerebral metabolism during citalopram treatment in the anterior cingulate gyrus, middle temporal gyrus, precuneus, amygdala, and parahippocampal gyrus. Increased metabolism was observed in the putamen, occipital cortex, and cerebellum. Functional connectivity analyses revealed two networks which were uniquely associated with improvement of affective symptoms and cognitive function during treatment. A subcortical-limbic-frontal network was associated with improvement in affect (depression and anxiety), while a medial temporal-parietal-frontal network was associated with improvement in cognition (immediate verbal learning/memory and verbal fluency). The regions that comprise the cognitive network overlap with the regions that are affected in Alzheimer's dementia. Thus, alterations in specific brain networks associated with improvement of affective symptoms and cognitive function are observed during citalopram treatment in geriatric depression.

Original languageEnglish (US)
Pages (from-to)1677-1691
Number of pages15
JournalHuman Brain Mapping
Volume32
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Fingerprint

Citalopram
Affective Symptoms
Geriatrics
Cognition
Depression
Glucose
Therapeutics
Verbal Learning
Occipital Lobe
Parahippocampal Gyrus
Neurobehavioral Manifestations
Parietal Lobe
Putamen
Gyrus Cinguli
Serotonin Uptake Inhibitors
Brain
Temporal Lobe
Amygdala
Positron-Emission Tomography
Cerebellum

Keywords

  • Aging
  • Citalopram
  • Depression
  • Functional connectivity
  • Glucose metabolism
  • Partial least squares (PLS)
  • Positron emission tomography (PET)
  • Selective serotonin reuptake inhibitors
  • Serotonin

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression. / Diaconescu, Andreea Oliviana; Kramer, Elisse; Hermann, Carol; Ma, Yilong; Dhawan, Vijay; Chaly, Thomas; Eidelberg, David; Mcintosh, Anthony Randal; Smith, Gwenn.

In: Human Brain Mapping, Vol. 32, No. 10, 10.2011, p. 1677-1691.

Research output: Contribution to journalArticle

Diaconescu, Andreea Oliviana ; Kramer, Elisse ; Hermann, Carol ; Ma, Yilong ; Dhawan, Vijay ; Chaly, Thomas ; Eidelberg, David ; Mcintosh, Anthony Randal ; Smith, Gwenn. / Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression. In: Human Brain Mapping. 2011 ; Vol. 32, No. 10. pp. 1677-1691.
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